A. Bunyaratvej, S. Sahaphong, N. Bhamarapravati, P. Wasi Different patterns of intraerythrocytic inclusion body distribution in the two types of haemoglobin H disease. An ultrastructural study. Acta Haematologica. Vol.69, No.5 (1983), 314-318. doi:10.1159/000206975 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30534
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Different patterns of intraerythrocytic inclusion body distribution in the two types of haemoglobin H disease. An ultrastructural study
Electron microscopic examination of intraerythrocytic inclusion bodies induced by methylene blue was carried out in 7 non-splenectomized patients with haemoglobin (Hb) H disease. In classical Hb H disease with the genotype of α-thalassaemia 1/α-thalassaemia 2 the inclusion bodies were mostly membrane-associated. In contrast, in Hb H disease of α-thalassaemia 1/Hb Constant Spring genotype the majority of inclusion bodies were in a floating stage. Possible mechanisms for the unexpected difference are discussed.
