Publication: Sensitivity of multiple first trimester sonomarkers in fetal aneuploidy detection
Issued Date
2015-01-01
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ISSN
16193997
03005577
03005577
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2-s2.0-84946149743
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Perinatal Medicine. Vol.43, No.3 (2015), 359-365
Suggested Citation
Pharuhas Chanprapaph, Chitnapin Dulyakasem, Buraya Phattanchindakun Sensitivity of multiple first trimester sonomarkers in fetal aneuploidy detection. Journal of Perinatal Medicine. Vol.43, No.3 (2015), 359-365. doi:10.1515/jpm-2014-0201 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36750
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Title
Sensitivity of multiple first trimester sonomarkers in fetal aneuploidy detection
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Abstract
Background: Multiple first trimester aneuploidy sono-markers have been introduced recently. Objective: To evaluate the efficacy of first trimester sono-markers in fetal aneuploidy detection without serum markers. Methods: There were entirely 280 fetuses with 11-13+6 weeks' gestation (crown-rumplength between 45-84 mm) enrolled to assess nuchal translucency thickness (NT), nasal bone (NB), tricuspid regurgitation (TR) and ductus venosus (DV) flow. The performance of each single marker and multiple markers for major fetal aneuploidy screening were determined. Results: Totally, 190 fetuses (67.85%) underwent invasive prenatal diagnosis with 14 major chromosome abnormalities identified including 4 cases of trisomy 21, 4 cases of trisomy 18, 3 cases of trisomy 13 and 3 cases of 45, XO. NT was the most accurate single marker with sensitivity of 71.43% and false-positive rate (FPR) of 4.14% while NB or TR was the most specific marker (99.6%) but lacked sensitivity. Among multiple first trimester-screening sono-markers, NT plus TR evaluation were the most sensitive test (78.57%) with FPR of 4.76%. Conclusion: NT was the most accurate first trimester-screening marker for fetal aneuploidy. NT plus TR assessment as double-screening markers could improve the sensitivity by 7% leading to the lower number of unnecessary invasive prenatal diagnosis.