Publication: Localization of Vibrio cholerae O1 in the intestinal tissue
Issued Date
1993-12-01
Resource Type
ISSN
0125877X
Other identifier(s)
2-s2.0-0027858923
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.11, No.2 (1993), 155-165
Suggested Citation
R. Sincharoenkul, W. Chaicumpa, E. Pongponratn, J. Limpananont, P. Tapchaisri, T. Kalambaheti, M. Chongsa-Nguan Localization of Vibrio cholerae O1 in the intestinal tissue. Asian Pacific Journal of Allergy and Immunology. Vol.11, No.2 (1993), 155-165. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22615
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Localization of Vibrio cholerae O1 in the intestinal tissue
Other Contributor(s)
Abstract
Colonization of V. cholerae O1 in vivo is known to be a non-invasive type which the vibrios are confined only to the intestinal tissues. The pathway by which the vibrio antigens reach the lymphoid cells and subsequently give rise to the immune responses is not entirely clear. Thus, experiments were performed in experimental rats by inoculating live V. cholerae O1 into the ligated ileal loops. The fate of the vibrios in the intestinal tissues was then studied by transmission electron microscopy at different times after the inoculation. It was concluded that live V. cholerae/O1 were initially taken up by the M cells which overlay Peyer's patches and which subsequently delivered the intact vibrios to phagocytic cells in the Peyer's patches. These phagocytic cells processed (digested) the vibrios while the lymphocytes and plasma cells infiltrated around them. During the late period of infection (12-15 hours after inoculation of the vibrios), vibrios were also found passing through the loose intercellular spaces between the absorptive epithelial cells into the underlying intestinal tissues.