Publication: Microbial degradation of halogenated aromatics: molecular mechanisms and enzymatic reactions
Issued Date
2020-01-01
Resource Type
ISSN
17517915
17517907
17517907
Other identifier(s)
2-s2.0-85073998547
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Microbial Biotechnology. Vol.13, No.1 (2020), 67-86
Suggested Citation
Panu Pimviriyakul, Thanyaporn Wongnate, Ruchanok Tinikul, Pimchai Chaiyen Microbial degradation of halogenated aromatics: molecular mechanisms and enzymatic reactions. Microbial Biotechnology. Vol.13, No.1 (2020), 67-86. doi:10.1111/1751-7915.13488 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/49554
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Microbial degradation of halogenated aromatics: molecular mechanisms and enzymatic reactions
Other Contributor(s)
Abstract
© 2019 The Authors. Microbial Biotechnology published by Society for Applied Microbiology and John Wiley & Sons Ltd and Society for Applied Microbiology. Halogenated aromatics are used widely in various industrial, agricultural and household applications. However, due to their stability, most of these compounds persist for a long time, leading to accumulation in the environment. Biological degradation of halogenated aromatics provides sustainable, low-cost and environmentally friendly technologies for removing these toxicants from the environment. This minireview discusses the molecular mechanisms of the enzymatic reactions for degrading halogenated aromatics which naturally occur in various microorganisms. In general, the biodegradation process (especially for aerobic degradation) can be divided into three main steps: upper, middle and lower metabolic pathways which successively convert the toxic halogenated aromatics to common metabolites in cells. The most difficult step in the degradation of halogenated aromatics is the dehalogenation step in the middle pathway. Although a variety of enzymes are involved in the degradation of halogenated aromatics, these various pathways all share the common feature of eventually generating metabolites for utilizing in the energy-producing metabolic pathways in cells. An in-depth understanding of how microbes employ various enzymes in biodegradation can lead to the development of new biotechnologies via enzyme/cell/metabolic engineering or synthetic biology for sustainable biodegradation processes.