Publication: Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar
Issued Date
2008-07-01
Resource Type
ISSN
00664804
Other identifier(s)
2-s2.0-46249096629
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy. Vol.52, No.7 (2008), 2657-2659
Suggested Citation
Mallika Imwong, Sasithon Pukrittayakamee, Wirichada Pongtavornpinyo, Supatchara Nakeesathit, Shalini Nair, Paul Newton, Francois Nosten, Timothy J.C. Anderson, Arjen Dondorp, Nicholas P.J. Day, Nicholas J. White Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar. Antimicrobial Agents and Chemotherapy. Vol.52, No.7 (2008), 2657-2659. doi:10.1128/AAC.01459-07 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/19630
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Title
Gene amplification of the multidrug resistance 1 gene of Plasmodium vivax isolates from Thailand, Laos, and Myanmar
Abstract
Plasmodium vivax mdr1 gene amplification, quantified by real-time PCR, was significantly more common on the western Thailand border (6 of 66 samples), where mefloquine pressure has been intense, than elsewhere in southeast Asia (3 of 149; P = 0.02). Five coding mutations in pvmdr1, independent of gene amplification, were also found. Copyright © 2008, American Society for Microbiology. All Rights Reserved.