Publication: Antibody-Enhanced Binding of Dengue-2 Virus to Human Platelets
Issued Date
1995-10-20
Resource Type
ISSN
10960341
00426822
00426822
Other identifier(s)
2-s2.0-0028845186
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Virology. Vol.213, No.1 (1995), 254-257
Suggested Citation
Songli Wang, Runtao He, Jintana Patarapotikul, Bruce L. Innis, Robert Anderson Antibody-Enhanced Binding of Dengue-2 Virus to Human Platelets. Virology. Vol.213, No.1 (1995), 254-257. doi:10.1006/viro.1995.1567 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17292
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Title
Antibody-Enhanced Binding of Dengue-2 Virus to Human Platelets
Abstract
The mechanisms underlying severe thrombocytopenia in dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) are not completely understood. We present here the first evidence that dengue type 2 virus binds to human platelets only in the presence of virus-specific antibody, supporting a role for immune-mediated clearance of platelets in the pathogenesis of thrombocytopenia in DHF/DSS. Antibody-enhanced binding of virus of platelets was also demonstrated with a panel of eight murine monoclonal antibodies specific for the dengue E protein. The degree of binding was dependent on the antibody used but not on the antibody IgG subclass, indicating that factors other than the platelet Fc receptor are involved in binding of virus-antibody complexes to the platelet surface. Confirmation that antibody-dependent virus binding to platelets is not primarily mediated by the platelet Fc receptor was obtained by demonstrating good binding even when platelets were pretreated with the FcγRII-specific antibody IV.3. © 1995 Academic Press. All rights reserved.