Publication: Linkage disequilibrium structure of the 5q31-33 region in a Thai population
Issued Date
2008-09-01
Resource Type
ISSN
14345161
Other identifier(s)
2-s2.0-50249148885
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Human Genetics. Vol.53, No.9 (2008), 850-856
Suggested Citation
Pornlada Nuchnoi, Jun Ohashi, Izumi Naka, Duangporn Nacapunchai, Katsushi Tokunaga, Nao Nishida, Jintana Patarapotikul Linkage disequilibrium structure of the 5q31-33 region in a Thai population. Journal of Human Genetics. Vol.53, No.9 (2008), 850-856. doi:10.1007/s10038-008-0309-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18869
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Linkage disequilibrium structure of the 5q31-33 region in a Thai population
Other Contributor(s)
Abstract
A number of loci related to the immune response are located on human chromosomal region 5q31-33, and polymorphisms in this region have been reported to be associated with autoimmune and infectious diseases. In Southeast Asian populations, no systematic survey with dense SNP markers has been performed for the 5q31-33 region. In this study, the LD and haplotype structures for a 472-kb region on 5q31 were investigated in a Thai population to provide useful information for association studies. In addition, the LD structure in Thais was compared with that of the CHB and JPT HapMap populations (CHB + JPT) to evaluate the transferability of tagging SNPs from CHB + JPT for Thais. We show that the minor allele frequency, pattern of LD block, and genetic structure in the 5q31-33 region were highly concordant between Thais and CHB + JPT. A high transferability of tagging SNPs from CHB + JPT for Thais was observed. Our results suggest that tagging SNPs from CHB + JPT (Northeast Asians) can efficiently capture common variants in Southeast Asians, and that the HapMap data are useful for association studies in Southeast Asian populations. © 2008 The Japan Society of Human Genetics and Springer.