Publication: Paraoxonasel phenotype distribution in thais
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Issued Date
2009-03-01
Resource Type
ISSN
01252208
01252208
01252208
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2-s2.0-63449120451
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.92, No.3 (2009), 405-412
Suggested Citation
Sureerut Porntadavity, Soontharee Tantrarongroj, Phanee Pidetcha, Prabhop Dansethakul, Lerson Suwannathon Paraoxonasel phenotype distribution in thais. Journal of the Medical Association of Thailand. Vol.92, No.3 (2009), 405-412. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/28143
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Title
Paraoxonasel phenotype distribution in thais
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Abstract
Objective: To determine the PON1 activity and phenotype distribution in a Thai population. Study design: Prospective Descriptive study. Material and Method: Between October 2001 and April 2002, 160 healthy Thai individuals aged 20-74 years were assessed for PON1 activity and the phenotype distribution by using dual substrate method. Results: The means ± SD of basal, salt-stimulated paraoxonase and arylesterase activities were 239.7 ± 83.9 nmol/min/mL 555.2 ± 222.2 nmol/min/mL and 147.6 ± 33.8 μmol/min/mL respectively. The authors observed a wide interindividual variability up to 6.9-fold for paraoxonase activity and 4.6-fold for arylesterase activity. The authors found a range of ssPON/ARE ratio from 1.04 to 7.05 and three distinctive phenotype modals of AA (1.04-2.25), AB (2.44-4.29), and BB (4.53-7.05) with frequencies of 14.4% (AA), 51.9% (AB), and 33.7% (BB). The authors also observed the association of sex with lipid parameters and PON1 activity. Conclusion: The distribution of PON1 phenotype in Thais is clearly trimodal with high frequency in BB phenotype.