Publication: Induction and transmission of oncogene-induced senescence
Issued Date
2020-01-01
Resource Type
ISSN
14209071
1420682X
1420682X
Other identifier(s)
2-s2.0-85091118777
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Mahidol University
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SCOPUS
Bibliographic Citation
Cellular and Molecular Life Sciences. (2020)
Suggested Citation
Nattaphong Rattanavirotkul, Kristina Kirschner, Tamir Chandra Induction and transmission of oncogene-induced senescence. Cellular and Molecular Life Sciences. (2020). doi:10.1007/s00018-020-03638-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/59003
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Title
Induction and transmission of oncogene-induced senescence
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Abstract
© 2020, The Author(s). Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially described as a paracrine mechanism, but recent evidence suggests a more complex scenario involving juxtacrine communication between cells. In addition, single-cell studies described differences between primary and secondary senescent end-points, which have thus far not been considered functionally distinct. Here we discuss emerging concepts in senescence transmission and heterogeneity in primary and secondary senescence on a cellular and organ level.