Publication: Chaperonomics in leptospirosis
Issued Date
2018-07-03
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ISSN
17448387
14789450
14789450
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2-s2.0-85051562550
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Mahidol University
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SCOPUS
Bibliographic Citation
Expert Review of Proteomics. Vol.15, No.7 (2018), 569-579
Suggested Citation
Arada Vinaiphat, Visith Thongboonkerd Chaperonomics in leptospirosis. Expert Review of Proteomics. Vol.15, No.7 (2018), 569-579. doi:10.1080/14789450.2018.1500901 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45105
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Title
Chaperonomics in leptospirosis
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Abstract
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Knowledge of the function of molecular chaperones is required for a better understanding of cellular proteostasis. Nevertheless, such information is currently dispersed as most of previous studies investigated chaperones on a single-angle basis. Recently, a new subdiscipline of chaperonology, namely ‘chaperonomics’ (defined as ‘systematic analysis of chaperone genes, transcripts, proteins, or their interaction networks using omics technologies’), has been emerging to better understand biological, physiological, and pathological roles of chaperones. Areas covered: This review provides broad overviews of bacterial chaperones, heat shock proteins (HSPs), and leptospirosis, and then focuses on recent progress of chaperonomics applied to define roles of HSPs in various pathogenic and saprophytic leptospiral species and serovars. Expert commentary: Comprehensive analysis of leptospiral chaperones/HSPs using a chaperonomics approach holds great promise for better understanding of functional roles of chaperones/HSPs in bacterial survival and disease pathogenesis. Moreover, this new approach may also lead to further development of chaperones/HSPs-based diagnostics and/or vaccine discovery for leptospirosis.