Publication:
Hemoglobin dhonburi α<inf>2</inf>β<inf>2</inf>126 (H4) Val → Gly: A new unstable β variant producing a β‐thalassemia intermedia phenotype in association with β°‐Thalassemia

1

Issued Date

1990-01-01

Resource Type

Article

ISSN

10968652
03618609

DOI

10.1002/ajh.2830350206

Other identifier(s)

2-s2.0-0025044955

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

American Journal of Hematology. Vol.35, No.2 (1990), 96-99

Suggested Citation

J. Bardakdjian‐Michau, J. Delanoe‐Garin, C. Lacombe, Y. Blouquit, J. Riou, F. Galacteros, S. Fucharoen, P. Winichagoon, P. Wasi, J. Kister Hemoglobin dhonburi α<inf>2</inf>β<inf>2</inf>126 (H4) Val → Gly: A new unstable β variant producing a β‐thalassemia intermedia phenotype in association with β°‐Thalassemia. American Journal of Hematology. Vol.35, No.2 (1990), 96-99. doi:10.1002/ajh.2830350206 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/16166

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Title

Hemoglobin dhonburi α<inf>2</inf>β<inf>2</inf>126 (H4) Val → Gly: A new unstable β variant producing a β‐thalassemia intermedia phenotype in association with β°‐Thalassemia

Author(s)

J. Bardakdjian‐Michau
 J. Delanoe‐Garin
 C. Lacombe
 Y. Blouquit
 J. Riou
 F. Galacteros
 S. Fucharoen
 P. Winichagoon
 P. Wasi
 J. Kister

Other Contributor(s)

Hopital Henri Mondor
 Faculty of Medicine, Siriraj Hospital, Mahidol University
 Inserm

Abstract

While investigating the mechanism of a β‐thalassemia intermedia phenotype in a 34 year old Thai male, a new Hb variant β 126 Val → Gly named Hb Dhonburi was discovered. Genetic and structural studies revealed the existence of a β°‐thalassemia genotype in association with the β variant. The new variant is unstable but exhibits normal oxygen binding properties. Hb Dhonburi was also discovered in the mother of the propositus in association with Hb E. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/16166

Collections

Scopus 1969-1990