Publication: P53 polymorphism at codon 72 is associated with keratocystic odontogenic tumors in the thai population
Issued Date
2015-01-01
Resource Type
ISSN
15137368
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2-s2.0-84928523527
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Cancer Prevention. Vol.16, No.5 (2015), 1997-2001
Suggested Citation
Pattamawadee Yanatatsaneejit, Ajaree Boonsrang, Apiwat Mutirangura, Vyomesh Patel, Nakarin Kitkumthorn P53 polymorphism at codon 72 is associated with keratocystic odontogenic tumors in the thai population. Asian Pacific Journal of Cancer Prevention. Vol.16, No.5 (2015), 1997-2001. doi:10.7314/APJCP.2015.16.5.1997 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35613
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Title
P53 polymorphism at codon 72 is associated with keratocystic odontogenic tumors in the thai population
Abstract
Objective: To clarify the association between the p53 polymorphism at codon 72 and susceptibility to the sporadic keratocystic odontogenic tumor (KCOT). Design: One hundred KCOTs and 160 match-group healthy controls were genotyped to ascertain the frequency of the p53 codon 72 polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), confirmed by direct sequencing. Results: The frequencies of the Pro/Pro, Arg/Pro, and Arg/Arg genotypes were 23.8%, 49.4%, and 26.9%, respectively, in the controls, while the KCOT cohort demonstrated 43.0%, 39.0%, and 18.0%, respectively. Further analysis suggested that p53 Pro could be a KCOT-susceptible allele (OR (95%CI)=1.77 (1.22 to 2.59), p=0.0024), with a sex-adjusted OR (95%CI) of 1.71 (1.17-2.50), p=0.0046. Moreover, the results indicated that p53 codon 72 Pro homozygous was associated with a two-fold risk of developing KCOT (adjusted OR (95%CI) =2.17(1.23-3.84), p=0.0062). Conclusions: The C/C genotype of P53 gene codon 72 increases the risk of developing sporadic KCOT and may be a useful tool for screening and diagnostic purposes.