Publication: The impact of prenatal organophosphate pesticide exposures on thai infant neurodevelopment
Issued Date
2017-06-01
Resource Type
ISSN
16604601
16617827
16617827
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2-s2.0-85020015947
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Environmental Research and Public Health. Vol.14, No.6 (2017)
Suggested Citation
Pornpimol Kongtip, Benyachalee Techasaensiri, Noppanun Nankongnab, Jane Adams, Akkarat Phamonphon, Anu Surach, Supha Sangprasert, Aree Thongsuksai, Prayoon Srikumpol, Susan Woskie The impact of prenatal organophosphate pesticide exposures on thai infant neurodevelopment. International Journal of Environmental Research and Public Health. Vol.14, No.6 (2017). doi:10.3390/ijerph14060570 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42687
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Title
The impact of prenatal organophosphate pesticide exposures on thai infant neurodevelopment
Abstract
© 2017 by the authors. Licensee MDPI, Basel, Switzerland. A birth cohort was begun to investigate the levels and sources of pesticide exposure in pregnant women living in Thailand, and to examine the effects of pesticide exposure on infant neurodevelopment at five months of age. Subjects were interviewed using questionnaires regarding their demographic characteristics, educational background, and work and home activities related to pesticide exposures. Spot urine samples were collected at 28 weeks gestation and analyzed by gas chromatography-mass spectrometry to determine maternal metabolite levels of organophosphate pesticides including dimethyl phosphate (DMP); total DEP (diethyl phosphate (DEP), diethyl thiophosphate (DETP), and diethyl dithiophosphate (DEDTP), and total DAP (the sum of all metabolite levels). At five months of age, infant development was evaluated using the Bayley Scales of Infant and Toddler Development-III (Bayley-III). Higher total DEP and total DAP metabolite levels from the mother at 28 weeks’ gestation were significantly associated with reduced motor composite scores on the Bayley-III at five months of age. The total DEP levels were also significantly associated with reduced cognitive composite scores. Prenatal concentrations of maternal urinary metabolites were associated with infant cognitive and motor development. The results of several studies now suggest the need for public health intervention to reduce prenatal pesticide exposures from both agricultural and domestic use.