Publication: Design and synthesis of C-12 dithiocarbamate andrographolide analogues as an anticancer agent
Issued Date
2020-07-15
Resource Type
ISSN
14643405
0960894X
0960894X
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2-s2.0-85084649114
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Mahidol University
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SCOPUS
Bibliographic Citation
Bioorganic and Medicinal Chemistry Letters. Vol.30, No.14 (2020)
Suggested Citation
Patcharee Arsakhant, Uthaiwan Sirion, Arthit Chairoungdua, Kanoknetr Suksen, Pawinee Piyachaturawat, Apichart Suksamrarn, Rungnapha Saeeng Design and synthesis of C-12 dithiocarbamate andrographolide analogues as an anticancer agent. Bioorganic and Medicinal Chemistry Letters. Vol.30, No.14 (2020). doi:10.1016/j.bmcl.2020.127263 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/56106
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Title
Design and synthesis of C-12 dithiocarbamate andrographolide analogues as an anticancer agent
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Abstract
© 2020 Elsevier Ltd A series of 21 new analogues of C-12 dithiocarbamate andrographolide was designed and synthesized from natural andrographolide isolated from a common Thai plant, Andrographis paniculata. The reaction used to manipulate the andrographolide scaffold was conducted in one pot under mild reaction conditions. This avoided toxic catalysts and gave nearly quantitative yields of new analogues, generally without by-products and can be easily scaled -up for industrial processing. All new analogues were evaluated against nine cancer cell lines, some analogues exhibited greater selective cytotoxic activity to MCF-7 cancer cell than that of the parent andrographolide and cancer drugs.