Publication: Shut‐down of virus synthesis during progression of erythroleukemia induced by friend virus in mice
Issued Date
1982-01-01
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ISSN
10970215
00207136
00207136
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2-s2.0-0019984122
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Cancer. Vol.29, No.6 (1982), 659-665
Suggested Citation
Chalobon Yoosook Shut‐down of virus synthesis during progression of erythroleukemia induced by friend virus in mice. International Journal of Cancer. Vol.29, No.6 (1982), 659-665. doi:10.1002/ijc.2910290610 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/30302
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Title
Shut‐down of virus synthesis during progression of erythroleukemia induced by friend virus in mice
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Abstract
Infection of (C57BL/6 × DBA/2)F1 (BDF1) mice with 2,500 FFU of Friend virus complex (FV) resulted in erythroleukemia followed by recovery, at which time virus could not be detected in the spleens of mice, and with splenomegaly (progressor mice) or without splenomegaly (regressor mice). Progressor and regressor mice developed equally high amounts of FV‐neutralizing activity in their sera. Progressor mice contained cells capable of producing virus, despite the lack of viral envelope antigen(s) in their spleens. The tropism of FV recoverable from the spleens of secondary recipients, injected with spleen cells from progressor mice, did not show any change, although the viral genome was present in Fv‐I‐restrictive host for at least 7 weeks. When the number of spleen colony‐generating cells was enumerated, by the spleen colony assay, the frequency in normal syngeneic and in allogeneic hosts was approximately the same at the early stage of erythroleukemia but was about 1,000 times higher in the syngeneic recipients during leukemia progression. These spleen colony‐generating cells were considered to be FV‐transformed cells capable of self‐renewal and capable of generating infectious centers (IC), respectively. Most of these transformed cells might be non‐producer leukemia cells. Copyright © 1982 Wiley‐Liss, Inc., A Wiley Company