Publication: Antiviral effect of PmRab7 knock-down on inhibition of Laem-Singh virus replication in black tiger shrimp
| dc.contributor.author | Chalermporn Ongvarrasopone | en_US |
| dc.contributor.author | Ekapol Chomchay | en_US |
| dc.contributor.author | Sakol Panyim | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.date.accessioned | 2018-09-24T09:04:08Z | |
| dc.date.available | 2018-09-24T09:04:08Z | |
| dc.date.issued | 2010-10-01 | en_US |
| dc.description.abstract | PmRab7 is a Penaeus monodon small GTPase protein possibly involved in replication of several shrimp viruses. In this study RNA interference (RNAi) using double-stranded RNA (dsRNA) targeting PmRab7 gene (dsRNA-PmRab7) was employed to silence the expression of PmRab7 to investigate the inhibitory effect on Laem-Singh virus (LSNV) replication. Injection of dsRNA-PmRab7 24. h before challenge with the virus resulted in a drastic decrease of PmRab7 mRNA and complete inhibition of LSNV replication at 3 days post-challenge. In a therapeutic mode, shrimp injected with dsRNA-PmRab7 1 day but not at 3 or 5 days post-LSNV challenge resulted in inhibition of LSNV replication. These results pave the way to use dsRNA-PmRab7 to prevent or cure LSNV infection in shrimp. © 2010 Elsevier B.V. | en_US |
| dc.identifier.citation | Antiviral Research. Vol.88, No.1 (2010), 116-118 | en_US |
| dc.identifier.doi | 10.1016/j.antiviral.2010.06.013 | en_US |
| dc.identifier.issn | 18729096 | en_US |
| dc.identifier.issn | 01663542 | en_US |
| dc.identifier.other | 2-s2.0-77956928010 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/20.500.14594/29187 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77956928010&origin=inward | en_US |
| dc.subject | Immunology and Microbiology | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Antiviral effect of PmRab7 knock-down on inhibition of Laem-Singh virus replication in black tiger shrimp | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77956928010&origin=inward | en_US |