Publication: Serological study of Toxoplasma gondii in kidney recipients
2
Issued Date
2001-08-01
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ISSN
01252208
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2-s2.0-0035431862
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.84, No.8 (2001), 1137-1141
Suggested Citation
Yaowalark Sukthana, Thaiyooth Chintana, Somnuek Damrongkitchaiporn, Amorn Lekkla Serological study of Toxoplasma gondii in kidney recipients. Journal of the Medical Association of Thailand. Vol.84, No.8 (2001), 1137-1141. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/26734
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Title
Serological study of Toxoplasma gondii in kidney recipients
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Abstract
Toxoplasma gondii IgG antibodies were determined in 200 kidney recipients by the Sabin-Felmand dye test. Twenty-two (11%) cases were positive for antibody detection. There was a statistically significant difference in the history of taking under-cooked meat, between the number of sero-positive cases and that of sero-negative subjects (63.6% vs 28.8%, p = 0.02). No such significant difference was evident regarding cat ownership (13.6% vs 22.0%, p = 0.3). Sixteen (72.6%) of the 22 subjects with positive T.gondii antibody had undergone kidney transplantation less than one year ago during which a high dose of immunosuppressive drugs were prescribed. The remaining six (27.3%) cases had had transplantation more than one year ago and were on a lower dosage of immunosuprresants. Toxoplasma reactivation seemed to be higher in the former group, which should thus be closely followed-up. Preventive chemoprophylaxis should be considered if there is any indication of toxoplasma reactivation. Since there have been occasional reports of donor-to-host transmission of toxoplasmosis in kidney transplant recipients, serological screening of toxoplasma antibody in kidney donors is advisable. Potential donors with positive toxoplasma antibody should be rejected; but if that is unavoidable, 6-week prophylactic treatment of primary infection in kidney recipients should be administered.