Publication: Pharmacokinetic investigation of albendazole and praziquantel in Thai children infected with Giardia intestinalis
9
Issued Date
2004-06-01
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ISSN
00034983
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2-s2.0-3142516059
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Mahidol University
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SCOPUS
Bibliographic Citation
Annals of Tropical Medicine and Parasitology. Vol.98, No.4 (2004), 349-357
Suggested Citation
K. Pengsaa, K. Na-Bangchang, K. Limkittikul, K. Kabkaew, K. Lapphra, C. Sirivichayakul, P. Wisetsing, C. Pojjaroen-Anant, P. Chanthavanich, A. Subchareon Pharmacokinetic investigation of albendazole and praziquantel in Thai children infected with Giardia intestinalis. Annals of Tropical Medicine and Parasitology. Vol.98, No.4 (2004), 349-357. doi:10.1179/000349804225003398 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21380
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Title
Pharmacokinetic investigation of albendazole and praziquantel in Thai children infected with Giardia intestinalis
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Abstract
The pharmacokinetics of albendazole/albendazole sulphoxide and praziquantel were investigated in Thai children with Giardia infection. Twenty school-age children were randomly allocated to receive either a single oral dose of albendazole (400 mg/child) or the same dose of albendazole given concurrently with a single oral dose of praziquantel (20 mg/kg). The concentrations of albendazole/albendazole sulphoxide and praziquantel in plasma samples, collected at intervals in the first 24 h post-treatment, were then quantified using HPLC with ultra-violet detection. No significant pharmacokinetic interaction between the albendazole and praziquantel was demonstrated. For albendazole sulphoxide, the active metabolite of albendazole, there was marked inter-individual variation in the maximum plasma concentration and the 'area under the curve'. The pharmacokinetics of albendazole sulphoxide were similar whether albendazole was given alone or in combination with praziquantel.