Publication: Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations
Issued Date
2008-05-01
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ISSN
00029165
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2-s2.0-43549123547
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Mahidol University
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SCOPUS
Bibliographic Citation
American Journal of Clinical Nutrition. Vol.87, No.5 (2008), 1238-1246
Suggested Citation
Supornpim Chearskul, Elizabeth Delbridge, Arthur Shulkes, Joseph Proietto, Adamandia Kriketos Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations. American Journal of Clinical Nutrition. Vol.87, No.5 (2008), 1238-1246. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/18744
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Title
Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations
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Abstract
Background: Weight regain after weight loss may not be due primarily to voluntary return to social habits but may be explained by changes in peripheral hormonal signals activating hunger and encouraging feeding behavior. Objective: The objective of this study was to investigate physiologic adaptations to weight loss that may encourage weight regain. Design: The study had a within-subject repeated-measure design [12 healthy, obese men, 33-64 y, body mass index (in kg/m2) 30-46] and was a clinical intervention investigation of circulating metabolites and hunger-satiety responses before and after weight loss. Measures included anthropometry (bioelectrical impedance, body weight, and waist circumference), concentrations of circulating hormones and metabolites [ketone bodies, free fatty acids (FFAs), insulin, leptin, glucose, and cholecystokinin (CCK)], and measures of hunger and satiety at baseline, 8 wk after weight loss with a very-low-energy diet, and 1 wk after weight maintenance. Results: Weight loss led to a reduction in postprandial CCK secretion (P = 0.016). However, when subjects were ketotic (elevated circulating β-hydroxybutyrate concentrations), CCK secretion was sustained at concentrations before weight loss. After weight loss, there were reduced postprandial FFA concentrations (P = 0.0005). The presence of ketosis sustained FFA to concentrations before weight loss (P = 0.60). Conclusion: Rapid weight loss of ≈10% of initial body weight results in a reduction in postprandial CCK and FFA concentrations. © 2008 American Society for Nutrition.