Publication: Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity
| dc.contributor.author | Cong Wang | en_US |
| dc.contributor.author | Adeep Monger | en_US |
| dc.contributor.author | Liping Wang | en_US |
| dc.contributor.author | Peng Fu | en_US |
| dc.contributor.author | Pawinee Piyachaturawat | en_US |
| dc.contributor.author | Arthit Chairoungdua | en_US |
| dc.contributor.author | Weiming Zhu | en_US |
| dc.contributor.other | Guangxi University for Nationalities | en_US |
| dc.contributor.other | Ocean University of China | en_US |
| dc.contributor.other | Chinese Academy of Sciences | en_US |
| dc.contributor.other | Mahidol University | en_US |
| dc.contributor.other | Qingdao National Laboratory for Marine Science and Technology | en_US |
| dc.date.accessioned | 2019-08-28T06:51:39Z | |
| dc.date.available | 2019-08-28T06:51:39Z | |
| dc.date.issued | 2018-05-01 | en_US |
| dc.description.abstract | © 2018 by the authors. One new indolocarbazole, 3-hydroxy-K252d (3), together with the recently reported 3-hydroxyholyrine A (1) and 3-N-acetyl-3-hydroxyholyrine A (2), were obtained by feeding a culture of the marine-derived Streptomyces strain OUCMDZ-3118 with 5-hydroxy-L-tryptophan. Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 potently induced apoptosis of gastric cancer cells by inhibiting topoisomerase IIα enzyme activity and reducing the expression of antiapoptosis protein level. Compound 3 displayed moderate cytotoxicity against the A549 and MCF-7 cell lines with IC50 values of 1.2 ± 0.05 µM, 1.6 ± 0.09 µM, respectively. | en_US |
| dc.identifier.citation | Marine Drugs. Vol.16, No.5 (2018) | en_US |
| dc.identifier.doi | 10.3390/md16050168 | en_US |
| dc.identifier.issn | 16603397 | en_US |
| dc.identifier.other | 2-s2.0-85047176616 | en_US |
| dc.identifier.uri | https://repository.li.mahidol.ac.th/handle/123456789/47312 | |
| dc.rights | Mahidol University | en_US |
| dc.rights.holder | SCOPUS | en_US |
| dc.source.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047176616&origin=inward | en_US |
| dc.subject | Pharmacology, Toxicology and Pharmaceutics | en_US |
| dc.title | Precursor-directed generation of indolocarbazoles with topoisomerase IIα inhibitory activity | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| mu.datasource.scopus | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047176616&origin=inward | en_US |