Publication: Intestinal calcium transport and its regulation in thalassemia: interaction between calcium and iron metabolism
Issued Date
2018-05-01
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18806546
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2-s2.0-85042542437
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Physiological Sciences. Vol.68, No.3 (2018), 221-232
Suggested Citation
Kornkamon Lertsuwan, Kannikar Wongdee, Jarinthorn Teerapornpuntakit, Narattaphol Charoenphandhu Intestinal calcium transport and its regulation in thalassemia: interaction between calcium and iron metabolism. Journal of Physiological Sciences. Vol.68, No.3 (2018), 221-232. doi:10.1007/s12576-018-0600-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/45178
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Title
Intestinal calcium transport and its regulation in thalassemia: interaction between calcium and iron metabolism
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Abstract
© 2018, The Physiological Society of Japan and Springer Japan KK, part of Springer Nature. Osteoporosis and derangement of calcium homeostasis are common complications of thalassemia. Despite being an important process for bone and calcium metabolism, little is known about intestinal calcium transport in thalassemia. Recent reports of decreases in both intestinal calcium transport and bone mineral density in thalassemic patients and animal models suggested that defective calcium absorption might be a cause of thalassemic bone disorder. Herein, the possible mechanisms associated with intestinal calcium malabsorption in thalassemia are discussed. This includes alterations in the calcium transporters and hormonal controls of the transcellular and paracellular intestinal transport systems in thalassemia. In addition, the effects of iron overload on intestinal calcium absorption, and the reciprocal interaction between iron and calcium transport in thalassemia are elaborated. Understanding the mechanisms underlining calcium malabsorption in thalassemia would lead to development of therapeutic agents and mineral supplements that restore calcium absorption as well as prevent osteoporosis in thalassemic patients.