Publication: Angiotensin II may mediate apoptosis via AT<inf>1</inf>-receptors in the rat cardiac conduction system
1
Issued Date
2004-01-01
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ISSN
14703203
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2-s2.0-6444241718
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Mahidol University
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SCOPUS
Bibliographic Citation
JRAAS - Journal of the Renin-Angiotensin-Aldosterone System. Vol.5, No.3 (2004), 135-140
Suggested Citation
Uraporn Vongvatcharanon, Surapong Vongvatcharanon, Nisaudah Radenahmad, Pornpimol Kirirat, Pranom Intasaro, Prasert Sobhon, Terry Parker Angiotensin II may mediate apoptosis via AT<inf>1</inf>-receptors in the rat cardiac conduction system. JRAAS - Journal of the Renin-Angiotensin-Aldosterone System. Vol.5, No.3 (2004), 135-140. doi:10.3317/jraas.2004.030 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/21245
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Title
Angiotensin II may mediate apoptosis via AT<inf>1</inf>-receptors in the rat cardiac conduction system
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Abstract
Apoptosis and angiotensin II (Ang II) have been suggested as possible causes of arrhythmias. In addition, Ang II via Ang II type I (AT1-) receptors, has been demonstrated to induce cardiomyocyte apoptosis. The transgenic m(Ren-2)27 (TG) rat carries the additional Ren-2 gene, the expression of which results in an increase in cardiac Ang II, thus potentially affecting the cell growth/death equilibrium. In this study we have investigated the effect of Ang II, via AT1-receptors, on mediating apoptosis in a cardiac conduction system (SA node and AV nodes).