Publication: Cytotoxic alkaloids from stems, leaves and twigs of Dasymaschalon blumei
Issued Date
2011-10-01
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ISSN
18736971
0367326X
0367326X
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2-s2.0-80052159186
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Mahidol University
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SCOPUS
Bibliographic Citation
Fitoterapia. Vol.82, No.7 (2011), 964-968
Suggested Citation
Waraporn Chanakul, Patoomratana Tuchinda, Natthinee Anantachoke, Manat Pohmakotr, Pawinee Piyachaturawat, Surawat Jariyawat, Kanoknetr Suksen, Tharworn Jaipetch, Narong Nuntasaen, Vichai Reutrakul Cytotoxic alkaloids from stems, leaves and twigs of Dasymaschalon blumei. Fitoterapia. Vol.82, No.7 (2011), 964-968. doi:10.1016/j.fitote.2011.05.012 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/12801
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Title
Cytotoxic alkaloids from stems, leaves and twigs of Dasymaschalon blumei
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Abstract
Bioassay-guided fractionation of the cytotoxic ethyl acetate extract from the stems of Dasymaschalon blumei (Annonaceae) led to the isolation of four aristololactam alkaloids, including the hitherto unknown 3,5-dihydroxy-2,4- dimethoxyaristolactam (1), as well as the three known compounds, aristolactam BI, goniopedaline, and griffithinam. Additionally, the cytotoxic extract from the combined leaves and twigs of the same plant yielded three known oxoaporphine alkaloids, oxodiscoguattine, dicentrinone, and duguevalline. The structures of aristolactams and oxoaporphine alkaloids were elucidated on the basis of spectroscopic methods. All isolates were evaluated for cytotoxicity against a panel of mammalian cancer cell lines and a noncancerous human embryonic kidney cell Hek 293. © 2011 Elsevier B.V.