Publication: Effect of acetylsalicylic acid on thalassemia with pulmonary arterial hypertension
Issued Date
2014-12-03
Resource Type
ISSN
11787074
Other identifier(s)
2-s2.0-84937542868
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of General Medicine. Vol.7, (2014), 525-529
Suggested Citation
Nonlawan Chueamuangphan, Wattana Wongtheptian, Jayanton Patumanond, Apichard Sukonthasarn, Suporn Chuncharunee, Chamaiporn Tawichasri, Weerasak Nawarawong Effect of acetylsalicylic acid on thalassemia with pulmonary arterial hypertension. International Journal of General Medicine. Vol.7, (2014), 525-529. doi:10.2147/IJGM.S71644 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/34152
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Effect of acetylsalicylic acid on thalassemia with pulmonary arterial hypertension
Abstract
© 2014 Chueamuangphan et al. Objective: To compare pulmonary artery systolic pressure (PASP) between thalassemic patients with pulmonary arterial hypertension (PAH) for whom acetylsalicylic acid (ASA) was and was not prescribed after 1 year. Methods: A retrospective cohort study was conducted at the hematological outpatient clinic at Chiang Rai Hospital, Chiang Rai, Thailand. All new cases of thalassemia with PAH from January 2007 to January 2012 were studied at the first month and at 12 months. The patients were classified into two groups. In one group, ASA 81 mg daily was prescribed for 1 year, whereas in another group no ASA was prescribed, due to its contraindications, which included bleeding, gastrointestinal side effects, and thrombocytopenia. PASP, estimated by a Doppler echocardiography, was measured by the same cardiologist. Propensity score adjustment was used to control confounding variables by indication and contraindication. Multivariable regression analysis was used to evaluate the effects of ASA.Results: Of the 63 thalassemia patients with PAH, there were 47 (74.6%) in the ASA group and 16 (25.4%) in the no ASA group. ASA, as compared with no ASA, did not significantly reduce PASP (adjusted difference -0.95; 95% confidence interval -16.99 to 15.10; P=0.906). Conclusion: Low-dose ASA may not have a beneficial effect on PASP after 1 year of treatment of PAH in thalassemia.