Publication: Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy
Issued Date
2016-04-01
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ISSN
21910251
0334018X
0334018X
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2-s2.0-84969262424
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Pediatric Endocrinology and Metabolism. Vol.29, No.4 (2016), 407-411
Suggested Citation
Linda Aurpibul, Sirintip Sricharoenchai, Orasri Wittawatmongkol, Virat Sirisanthana, Wanatpreeya Phongsamart, Tavitiya Sudjaritruk, Kulkanya Chokephaibulkit Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy. Journal of Pediatric Endocrinology and Metabolism. Vol.29, No.4 (2016), 407-411. doi:10.1515/jpem-2015-0203 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/43080
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Title
Vitamin D status in perinatally HIV-infected Thai children receiving antiretroviral therapy
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Abstract
© 2016 by De Gruyter. Background: Low vitamin D level is associated with adverse health outcomes and compromises HIV treatment response. We assess vitamin D status in HIV-infected Thai children receiving combination antiretroviral therapy (cART). Methods: A cross-sectional study in perinatally HIV-infected children. Vitamin D deficiency and vitamin D insufficiency were defined as serum 25-hydroxyvitamin D (25-OHD) level <20, and 21-29 ng/mL, respectively. Results: Eighty participants were enrolled. Their median age was 12.2 years. The median CD4 lymphocyte count was 784 cell/mm3; 95% had HIV RNA <50 copies/mL. The median (interquartile range, IQR) 25-OHD level was 33.5 (26.2-39.8) ng/mL. Thirty-four (43%) participants had low vitamin D level; 26 (33%) and 8 (10%) had vitamin D insufficiency and deficiency, respectively. In multivariate analysis, only geographic location was significantly associated with low vitamin D level. Conclusions: Most of perinatally HIV-infected children receiving cART had low vitamin D level. Calcium and vitamin D supplement might be beneficial.