Publication: Circulating microRNAs in malaria infection: Bench to bedside
Issued Date
2017-08-15
Resource Type
ISSN
14752875
Other identifier(s)
2-s2.0-85027873770
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Malaria Journal. Vol.16, No.1 (2017)
Suggested Citation
Supat Chamnanchanunt, Suthat Fucharoen, Tsukuru Umemura Circulating microRNAs in malaria infection: Bench to bedside. Malaria Journal. Vol.16, No.1 (2017). doi:10.1186/s12936-017-1990-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42762
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Circulating microRNAs in malaria infection: Bench to bedside
Other Contributor(s)
Abstract
© 2017 The Author(s). Severe malaria has a poor prognosis with a morbidity rate of 80% in tropical areas. The early parasite detection is one of the effective means to prevent severe malaria of which specific treatment strategies are limited. Many clinical characteristics and laboratory testings have been used for the early diagnosis and prediction of severe disease. However, a few of these factors could be applied to clinical practice. MicroRNAs (miRNAs) were demonstrated as useful biomarkers in many diseases such as malignant diseases and cardiovascular diseases. Recently it was found that plasma miR-451 and miR-16 were downregulated in malaria infection at parasitic stages or with multi-organ failure involvement. MiR-125b, -27a, -23a, -150, 17-92 and -24 are deregulated in malaria patients with multiple organ failures. Here, the current findings of miRNAs were reviewed in relation to clinical severity of malaria infection and emphasized that miRNAs are potential biomarkers for severe malaria infection.
