Publication: Blood-stage dynamics and clinical implications of mixed Plasmodium vivax-Plasmodium falciparum infections
Issued Date
1999-01-01
Resource Type
ISSN
00029637
Other identifier(s)
2-s2.0-0032870284
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Tropical Medicine and Hygiene. Vol.61, No.3 (1999), 367-374
Suggested Citation
Daniel P. Mason, F. Ellis Mckenzie Blood-stage dynamics and clinical implications of mixed Plasmodium vivax-Plasmodium falciparum infections. American Journal of Tropical Medicine and Hygiene. Vol.61, No.3 (1999), 367-374. doi:10.4269/ajtmh.1999.61.367 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25456
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Title
Blood-stage dynamics and clinical implications of mixed Plasmodium vivax-Plasmodium falciparum infections
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Abstract
We present a mathematical model of the blood-stage dynamics of mixed Plasmodium vivax-Plasmodium falciparum malaria infections in humans. The model reproduces features of such infections found in nature and suggests several phenomena that may merit clinical attention, including the potential recrudescence of a long-standing, low-level P. falciparum infection following a P. vivax infection or relapse and the capacity of an existing P. vivax infection to reduce the peak parasitemia of a P. falciparum superinfection. We simulate the administration of antimalarial drugs, and illustrate some potential complications in treating mixed-species malaria infections. Notably, our model indicates that when a mixed-species infection is misdiagnosed as a single-species P. vivax infection, treatment for P. vivax can lead to a surge in P. falciparum parasitemia.