Publication: Water-soluble β-cyclodextrin grafted with chitosan and its inclusion complex as a mucoadhesive eugenol carrier
Issued Date
2012-06-20
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ISSN
01448617
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2-s2.0-84861092919
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Mahidol University
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SCOPUS
Bibliographic Citation
Carbohydrate Polymers. Vol.89, No.2 (2012), 623-631
Suggested Citation
Warayuth Sajomsang, Onanong Nuchuchua, Pattarapond Gonil, Somsak Saesoo, Issara Sramala, Apinan Soottitantawat, Satit Puttipipatkhachorn, Uracha Rungsardthong Ruktanonchai Water-soluble β-cyclodextrin grafted with chitosan and its inclusion complex as a mucoadhesive eugenol carrier. Carbohydrate Polymers. Vol.89, No.2 (2012), 623-631. doi:10.1016/j.carbpol.2012.03.060 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/13962
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Title
Water-soluble β-cyclodextrin grafted with chitosan and its inclusion complex as a mucoadhesive eugenol carrier
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Abstract
Inclusion complex between water-soluble βCD-grafted chitosan derivatives (QCD-g-CS) and eugenol (EG) was investigated as a new type of mucoadhesive drug carrier. The QCD-g-CSs were synthesized with various βCD moieties ranging from 5 to 23%. Spontaneous inclusion complex of these derivatives and EG were found and confirmed by FTIR and simulation study. Self-aggregated formations of QCD-g-CS were found, according to fluorescence and TEM studies, where the formations were preferable for QCD11g-CS and QCD5-g-CS. EG can be included in both βCD hydrophobic cavity and hydrophobic core of QCD-g-CS self-aggregates, resulting in varying entrapment efficiencies. Degree of QCD substitution on QCD-g-CS plays an important role on their physical properties, due to steric hindrance. The QCD11-g-CS showed excellent mucoadhesion, compared to the QCD5-g-CS and QCD23-g-CS. Moreover, the inclusion complex between QCD-g-CS and EG tend to express higher antimicrobial activities against Candida albicans, Streptococcus oralis and Streptococcus mutans, than the native QCD-g-CS. © 2012 Elsevier Ltd. All rights reserved.