Publication: Potential health and economic impacts of dexamethasone treatment for patients with COVID-19
Issued Date
2021-12-01
Resource Type
ISSN
20411723
Other identifier(s)
2-s2.0-85101016964
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature Communications. Vol.12, No.1 (2021)
Suggested Citation
Ricardo Águas, Adam Mahdi, Rima Shretta, Peter Horby, Martin Landray, Lisa White, Fatima Arifi, Chynar Zhumalieva, Inke N.D. Lubis, Antoninho Benjamin Monteiro, Ainura Moldokmatova, Siyu Chen, Aida Estebesova, Mofakhar Hussain, Dipti Lata, Emmanuel A. Bakare, Biniam Getachew, Mohammad Nadir Sahak, Phetsavanh Chanthavilay, Akindeh M. Nji, Yu Nandar Aung, Nathaniel Hupert, Sai Thein Than Tun, Wirichada Pan-Ngum, K. C. Sarin, Handoyo Harsono, Sana Eybpoosh, Renato Mendes Coutinho, Semeeh A. Omoleke, Amen Patrick Nwosu, Nantasit Luangasanatip, Ainura Kutmanova, Aizhan Dooronbekova, Antonio Ximenes, Merita Monteiro, Olivier Celhay, Keyrellous Adib, Amel H. Salim, Yuki Yunanda, Mahnaz Hossain Fariba, Amirah Azzeri, Penny Hancock, Hakim Bekrizadeh, Sayed Ataullah Saeedzai, Ivana Alona, Grace Wezi Mzumara, Joao Martins, Jose L. Herrera-Diestra, Hamid Sharifi, Talant Abdyldaev, Babak Jamshidi, Noran Naqiah Hairi, Naima Nasir, Rashid U. Zaman, Sopuruchukwu Obiesie, Roberto A. Kraenkel, Nicholas Letchford, Lucsendar Raimunda Fernandes Alves, Sandra Adele, Lorena Suárez-Idueta, Nicole Advani, Manar Marzouk, Viviana Mabombo, Aibek Mukambetov, Adeniyi Kolade Aderoba, Bpriya Lakshmy Tbalasubramaniam, Nicole Feune de Colombi, Maria Angela Varela Niha, Francisco Obando, Parinda Wattanasri, Sompob Saralamba, Fatiha Shabaruddin, Shafiun Nahin Shimul, Maznah Dahlui, Reshania Naidoo, Caroline Franco, Michael G. Klein, Aisuluu Kubatova, Nusrat Jabin, Shwe Sin Kyaw, Luzia Tomas Freitas, Sunil Pokharel, Proochista Ariana, Chris Erwin G. Mercado, Shamil Ibragimov, John Robert C. Medina, Mesulame Namedre Potential health and economic impacts of dexamethasone treatment for patients with COVID-19. Nature Communications. Vol.12, No.1 (2021). doi:10.1038/s41467-021-21134-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/75950
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Potential health and economic impacts of dexamethasone treatment for patients with COVID-19
Author(s)
Ricardo Águas
Adam Mahdi
Rima Shretta
Peter Horby
Martin Landray
Lisa White
Fatima Arifi
Chynar Zhumalieva
Inke N.D. Lubis
Antoninho Benjamin Monteiro
Ainura Moldokmatova
Siyu Chen
Aida Estebesova
Mofakhar Hussain
Dipti Lata
Emmanuel A. Bakare
Biniam Getachew
Mohammad Nadir Sahak
Phetsavanh Chanthavilay
Akindeh M. Nji
Yu Nandar Aung
Nathaniel Hupert
Sai Thein Than Tun
Wirichada Pan-Ngum
K. C. Sarin
Handoyo Harsono
Sana Eybpoosh
Renato Mendes Coutinho
Semeeh A. Omoleke
Amen Patrick Nwosu
Nantasit Luangasanatip
Ainura Kutmanova
Aizhan Dooronbekova
Antonio Ximenes
Merita Monteiro
Olivier Celhay
Keyrellous Adib
Amel H. Salim
Yuki Yunanda
Mahnaz Hossain Fariba
Amirah Azzeri
Penny Hancock
Hakim Bekrizadeh
Sayed Ataullah Saeedzai
Ivana Alona
Grace Wezi Mzumara
Joao Martins
Jose L. Herrera-Diestra
Hamid Sharifi
Talant Abdyldaev
Babak Jamshidi
Noran Naqiah Hairi
Naima Nasir
Rashid U. Zaman
Sopuruchukwu Obiesie
Roberto A. Kraenkel
Nicholas Letchford
Lucsendar Raimunda Fernandes Alves
Sandra Adele
Lorena Suárez-Idueta
Nicole Advani
Manar Marzouk
Viviana Mabombo
Aibek Mukambetov
Adeniyi Kolade Aderoba
Bpriya Lakshmy Tbalasubramaniam
Nicole Feune de Colombi
Maria Angela Varela Niha
Francisco Obando
Parinda Wattanasri
Sompob Saralamba
Fatiha Shabaruddin
Shafiun Nahin Shimul
Maznah Dahlui
Reshania Naidoo
Caroline Franco
Michael G. Klein
Aisuluu Kubatova
Nusrat Jabin
Shwe Sin Kyaw
Luzia Tomas Freitas
Sunil Pokharel
Proochista Ariana
Chris Erwin G. Mercado
Shamil Ibragimov
John Robert C. Medina
Mesulame Namedre
Adam Mahdi
Rima Shretta
Peter Horby
Martin Landray
Lisa White
Fatima Arifi
Chynar Zhumalieva
Inke N.D. Lubis
Antoninho Benjamin Monteiro
Ainura Moldokmatova
Siyu Chen
Aida Estebesova
Mofakhar Hussain
Dipti Lata
Emmanuel A. Bakare
Biniam Getachew
Mohammad Nadir Sahak
Phetsavanh Chanthavilay
Akindeh M. Nji
Yu Nandar Aung
Nathaniel Hupert
Sai Thein Than Tun
Wirichada Pan-Ngum
K. C. Sarin
Handoyo Harsono
Sana Eybpoosh
Renato Mendes Coutinho
Semeeh A. Omoleke
Amen Patrick Nwosu
Nantasit Luangasanatip
Ainura Kutmanova
Aizhan Dooronbekova
Antonio Ximenes
Merita Monteiro
Olivier Celhay
Keyrellous Adib
Amel H. Salim
Yuki Yunanda
Mahnaz Hossain Fariba
Amirah Azzeri
Penny Hancock
Hakim Bekrizadeh
Sayed Ataullah Saeedzai
Ivana Alona
Grace Wezi Mzumara
Joao Martins
Jose L. Herrera-Diestra
Hamid Sharifi
Talant Abdyldaev
Babak Jamshidi
Noran Naqiah Hairi
Naima Nasir
Rashid U. Zaman
Sopuruchukwu Obiesie
Roberto A. Kraenkel
Nicholas Letchford
Lucsendar Raimunda Fernandes Alves
Sandra Adele
Lorena Suárez-Idueta
Nicole Advani
Manar Marzouk
Viviana Mabombo
Aibek Mukambetov
Adeniyi Kolade Aderoba
Bpriya Lakshmy Tbalasubramaniam
Nicole Feune de Colombi
Maria Angela Varela Niha
Francisco Obando
Parinda Wattanasri
Sompob Saralamba
Fatiha Shabaruddin
Shafiun Nahin Shimul
Maznah Dahlui
Reshania Naidoo
Caroline Franco
Michael G. Klein
Aisuluu Kubatova
Nusrat Jabin
Shwe Sin Kyaw
Luzia Tomas Freitas
Sunil Pokharel
Proochista Ariana
Chris Erwin G. Mercado
Shamil Ibragimov
John Robert C. Medina
Mesulame Namedre
Other Contributor(s)
HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences
Faculty of Tropical Medicine, Mahidol University
Institute of Health Policy, Management and Evaluation
Oxford Social Sciences Division
Valid International
Federal University, Oye-Ekiti
Ministry of Health East Timor
Ministry of Health Malawai
University of the Philippines Manila
Université de Yaoundé I
Universitas Sumatera Utara
Universiti Malaya
Payame Noor University
Organisation Mondiale de la Santé
University of Oxford
Menzies School of Health Research
Clinical Trial Service Unit and Epidemiological Studies Unit
University College London
Thailand Ministry of Public Health
San Jose State University
University of Nottingham
University of Dhaka
University of Malaya Medical Centre
Kermanshah University of Medical Sciences
Nuffield Department of Medicine
Population Services International
Cornell University
Universidade Estadual Paulista "Júlio de Mesquita Filho"
Pasteur Institute of Iran
London School of Economics and Political Science
Universidad De Los Andes, Merida
Universidade Federal do ABC
Oxford Policy Management
COVID-19 Task Force for North Sumatera province
University of Malaysia
Independent researcher (no affiliation)
Independent researcher (no affiliation)
Soros Foundation in the Kyrgyz Republic
Public Fund “Institution of social development” in the Kyrgyz Republic
University of Health Sciences
USAID Mission in the Kyrgyz Republic
Government of the People’s Republic of Bangladesh
Universidade Nacional Timor Lorosae
Fiji Centre for Communicable Disease Control
Universidade da Paz
Ministry of Health of the Kyrgyz Republic
Oxford Policy Management
Ministry of Public Health
Faculty of Tropical Medicine, Mahidol University
Institute of Health Policy, Management and Evaluation
Oxford Social Sciences Division
Valid International
Federal University, Oye-Ekiti
Ministry of Health East Timor
Ministry of Health Malawai
University of the Philippines Manila
Université de Yaoundé I
Universitas Sumatera Utara
Universiti Malaya
Payame Noor University
Organisation Mondiale de la Santé
University of Oxford
Menzies School of Health Research
Clinical Trial Service Unit and Epidemiological Studies Unit
University College London
Thailand Ministry of Public Health
San Jose State University
University of Nottingham
University of Dhaka
University of Malaya Medical Centre
Kermanshah University of Medical Sciences
Nuffield Department of Medicine
Population Services International
Cornell University
Universidade Estadual Paulista "Júlio de Mesquita Filho"
Pasteur Institute of Iran
London School of Economics and Political Science
Universidad De Los Andes, Merida
Universidade Federal do ABC
Oxford Policy Management
COVID-19 Task Force for North Sumatera province
University of Malaysia
Independent researcher (no affiliation)
Independent researcher (no affiliation)
Soros Foundation in the Kyrgyz Republic
Public Fund “Institution of social development” in the Kyrgyz Republic
University of Health Sciences
USAID Mission in the Kyrgyz Republic
Government of the People’s Republic of Bangladesh
Universidade Nacional Timor Lorosae
Fiji Centre for Communicable Disease Control
Universidade da Paz
Ministry of Health of the Kyrgyz Republic
Oxford Policy Management
Ministry of Public Health
Abstract
Dexamethasone can reduce mortality in hospitalised COVID-19 patients needing oxygen and ventilation by 18% and 36%, respectively. Here, we estimate the potential number of lives saved and life years gained if this treatment were to be rolled out in the UK and globally, as well as the cost-effectiveness of implementing this intervention. Assuming SARS-CoV-2 exposure levels of 5% to 15%, we estimate that, for the UK, approximately 12,000 (4,250 - 27,000) lives could be saved between July and December 2020. Assuming that dexamethasone has a similar effect size in settings where access to oxygen therapies is limited, this would translate into approximately 650,000 (240,000 - 1,400,000) lives saved globally over the same time period. If dexamethasone acts differently in these settings, the impact could be less than half of this value. To estimate the full potential of dexamethasone in the global fight against COVID-19, it is essential to perform clinical research in settings with limited access to oxygen and/or ventilators, for example in low- and middle-income countries.