Publication: Molecular basis of sequestration in severe and uncomplicated plasmodium falciparum malaria: Differential adhesion of infected erythrocytes to cd36 and icam-1
Issued Date
1991-01-01
Resource Type
ISSN
15376613
00221899
00221899
Other identifier(s)
2-s2.0-0025949090
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.164, No.1 (1991), 163-169
Suggested Citation
Christian F. Ockenhouse, May Ho, Narendra N. Tandon Molecular basis of sequestration in severe and uncomplicated plasmodium falciparum malaria: Differential adhesion of infected erythrocytes to cd36 and icam-1. Journal of Infectious Diseases. Vol.164, No.1 (1991), 163-169. doi:10.1093/infdis/164.1.163 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/22225
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Title
Molecular basis of sequestration in severe and uncomplicated plasmodium falciparum malaria: Differential adhesion of infected erythrocytes to cd36 and icam-1
Author(s)
Abstract
The CD36 and ICAM-1 glycoproteins on vascular endothelial cells have been implicated as cytoadherence receptors for Plasmodium falciparum-infected erythrocytes (IRBC). Adhesion of IRBC from Thai patients with uncomplicated and severe falciparum malaria to purified CD36 or ICAM-1 and to C32 melanoma cells was compared. All malaria isolates bound to solid phase- adsorbed CD36 and to fluid-phasemI-labeled CD36. IRBC adhesion to purified ICAM-1 varied widely, and no correlation with clinical severity of disease was observed. The cytoadherent phenotype of IRBC was modulated by selective panning on plates coated with purified CD36 or ICAM- 1. IRBC selected by panning on CD36+, ICAM-1+melanoma cells bound to cells that express surface CD36 but not to CD36-deficient cells, indicating that CD36 exerts a strong selective pressure on the IRBC cytoadherent phenotype. IRBC adhesion to CD36 and ICAM-1 suggests that P. falciparum parasites may use these receptors in vivo to promote parasite survival and immune evasion. © 1991 by The University of Chicago.