Publication: Mutations of ferric uptake regulator (fur) impair iron homeostasis, growth, oxidative stress survival, and virulence of Xanthomonas campestris pv. campestris
Issued Date
2010-05-01
Resource Type
ISSN
03028933
Other identifier(s)
2-s2.0-77952098034
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Archives of Microbiology. Vol.192, No.5 (2010), 331-339
Suggested Citation
Thichakorn Jittawuttipoka, Ratiboot Sallabhan, Paiboon Vattanaviboon, Mayuree Fuangthong, Skorn Mongkolsuk Mutations of ferric uptake regulator (fur) impair iron homeostasis, growth, oxidative stress survival, and virulence of Xanthomonas campestris pv. campestris. Archives of Microbiology. Vol.192, No.5 (2010), 331-339. doi:10.1007/s00203-010-0558-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/28724
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Mutations of ferric uptake regulator (fur) impair iron homeostasis, growth, oxidative stress survival, and virulence of Xanthomonas campestris pv. campestris
Abstract
Iron is essential in numerous cellular functions. Intracellular iron homeostasis must be maintained for cell survival and protection against iron's toxic effects. Here, we characterize the roles of Xanthomonas campestris pv. campestris (Xcc) fur, which encodes an iron sensor and a transcriptional regulator that acts in iron homeostasis, oxidative stress, and virulence. Herein, we isolated spontaneous Xcc fur mutants that had high intracellular iron concentrations due to constitutively high siderophore levels and increased expression of iron transport genes. These mutants also had reduced aerobic plating efficiency and resistance to peroxide killing. Moreover, one fur mutant was attenuated on a host plant, thus indicating that fur has important roles in the virulence of X. campestris pv. campestris. © 2010 Springer-Verlag.