Publication: Interferon lambda 1 is associated with dengue severity in Thailand
Issued Date
2020-04-01
Resource Type
ISSN
18783511
12019712
12019712
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2-s2.0-85080095292
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Infectious Diseases. Vol.93, (2020), 121-125
Suggested Citation
Unchana Arayasongsak, Izumi Naka, Jun Ohashi, Jintana Patarapotikul, Pornlada Nuchnoi, Thareerat Kalambaheti, Areerat Sa-Ngasang, Sumalee Chanama, Suwanna Chaorattanakawee Interferon lambda 1 is associated with dengue severity in Thailand. International Journal of Infectious Diseases. Vol.93, (2020), 121-125. doi:10.1016/j.ijid.2020.01.026 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/53720
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Title
Interferon lambda 1 is associated with dengue severity in Thailand
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Abstract
© 2020 The Authors Objectives: Patients with dengue exhibit a range of symptoms from an acute febrile illness (dengue fever, DF), to dengue hemorrhagic fever (DHF), and to the most severe outcome, dengue shock syndrome (DSS). This study was performed to determine the host genetic factors responsible for dengue severity. Two single nucleotide polymorphisms (SNPs) of the interferon lambda 1 (IFNL1) gene (rs30461 and rs7247086) were analyzed for their association with dengue severity in a Thai population. Methods: This was a case–control association study involving 877 patients under the age of 15 years (DF, n = 386; DHF, n = 416; DSS, n = 75). Genotyping was performed by TaqMan real-time PCR assay. Results: It was found that the rs7247086 variant of IFNL1 was associated with DHF, but not DSS. Genotypes CT and TT and the T allele were protective against DHF (p = 0.03, odds ratio 0.62 for CT, odds ratio 0.13 for TT; and p = 0.01, odds ratio 0.54 for the T allele). The other SNP tested was not associated with DHF or DSS. Conclusions: The rs7247086 variant of IFNL1 (the T allele) was found to be protective against DHF, suggesting that IFNL1 may play a role in the pathogenesis of DHF.