Publication: Drug-induced angioedema without urticaria: Prevalence and clinical features
Issued Date
2010-01-01
Resource Type
ISSN
14683083
09269959
09269959
Other identifier(s)
2-s2.0-77952145111
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the European Academy of Dermatology and Venereology. Vol.24, No.6 (2010), 685-691
Suggested Citation
C. Leeyaphan, K. Kulthanan, K. Jongjarearnprasert, N. Dhana Drug-induced angioedema without urticaria: Prevalence and clinical features. Journal of the European Academy of Dermatology and Venereology. Vol.24, No.6 (2010), 685-691. doi:10.1111/j.1468-3083.2009.03489.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29815
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Drug-induced angioedema without urticaria: Prevalence and clinical features
Other Contributor(s)
Abstract
Background Angioedema without urticaria can be caused by drugs. The purpose of our study was to assess the prevalence and clinical features of patients with drug-induced angioedema without urticaria. Methods This study retrospectively reviewed case records at Siriraj Hospital, between January 2007 and December 2008. Patients aged at least 15 years were included. Results The prevalence of drug-induced angioedema without urticaria among patients with adverse drug reactions was 2.3%/year. Non-steroidal anti-inflammatory drugs (NSAID) were the most common cause (50%), followed by antibiotics (20%). The commonest NSAID which induced angioedema were ibuprofen and diclofenac. The common sites were periorbital area (67.3%) and lips (27.6%). The median duration of suspected drug therapy before the development of angioedema was 1 day with the range of 10 min to 23 days. Conclusions Non-steroidal anti-inflammatory drugs and antibiotics were the most common drugs causing angioedema without urticaria. The duration of onset ranged from minutes to days. After stopping the suspected drugs, symptoms disappeared within 2-5 days in most patients. © 2009 European Academy of Dermatology and Venereology.