Publication: Household transmission of carbapenemase-producing Enterobacteriaceae: A prospective cohort study
Issued Date
2021-05-01
Resource Type
ISSN
14602091
03057453
03057453
Other identifier(s)
2-s2.0-85104900020
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Antimicrobial Chemotherapy. Vol.76, No.5 (2021), 1299-1302
Suggested Citation
Kalisvar Marimuthu, Yin Mo, Moi Lin Ling, Anastasia Hernandez-Koutoucheva, Shannon N. Fenlon, Denis Bertrand, David Chien Lye, Brenda Sze Peng Ang, Eli Perencevich, Oon Tek Ng, Ben S. Cooper, Niranjan Nagarajan, Swaine L. Chen, Timothy Barkham Household transmission of carbapenemase-producing Enterobacteriaceae: A prospective cohort study. Journal of Antimicrobial Chemotherapy. Vol.76, No.5 (2021), 1299-1302. doi:10.1093/jac/dkaa561 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78249
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Title
Household transmission of carbapenemase-producing Enterobacteriaceae: A prospective cohort study
Other Contributor(s)
National Centre for Infectious Diseases
Faculty of Tropical Medicine, Mahidol University
National University Hospital
A-Star, Genome Institute of Singapore
NUS Yong Loo Lin School of Medicine
Singapore General Hospital
University of Iowa Carver College of Medicine
Nuffield Department of Medicine
Nanyang Technological University
Tan Tock Seng Hospital
Faculty of Tropical Medicine, Mahidol University
National University Hospital
A-Star, Genome Institute of Singapore
NUS Yong Loo Lin School of Medicine
Singapore General Hospital
University of Iowa Carver College of Medicine
Nuffield Department of Medicine
Nanyang Technological University
Tan Tock Seng Hospital
Abstract
Objectives: To estimate the transmission rate of carbapenemase-producing Enterobacteriaceae (CPE) in households with recently hospitalized CPE carriers. Methods: We conducted a prospective case-ascertained cohort study. We identified the presence of CPE in stool samples from index subjects, household contacts and companion animals and environmental samples at regular intervals. Linked transmissions were identified by WGS. A Markov model was constructed to estimate the household transmission potential of CPE. Results: Ten recently hospitalized index patients and 14 household contacts were included. There were seven households with one contact, two households with two contacts, and one household with three contacts. Index patients were colonized with blaOXA-48-like (n=4), blaKPC-2 (n=3), blaIMP (n=2), and blaNDM-1 (n=1), distributed among divergent species of Enterobacteriaceae. After a cumulative follow-up time of 9.0 years, three family members (21.4%, 3/14) acquired four different types of CPE in the community (hazard rate of 0.22/year). The probability of CPE transmission from an index patient to a household contact was 10% (95% CI 4%-26%). Conclusions: We observed limited transmission of CPE from an index patient to household contacts. Larger studies are needed to understand the factors associated with household transmission of CPE and identify preventive strategies.