Publication: Diarylheptanoids of curcuma comosa with inhibitory effects on nitric oxide production in macrophage RAW 264.7 Cells
Issued Date
2015-01-01
Resource Type
ISSN
15559475
1934578X
1934578X
Other identifier(s)
2-s2.0-84937563552
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Natural Product Communications. Vol.10, No.1 (2015), 89-93
Suggested Citation
Nilubon Sornkaew, Yuan Lin, Fei Wang, Guolin Zhang, Ratchanaporn Chokchaisiri, Ailian Zhang, Kanjana Wongkrajang, Parichat Suebsakwong, Pawinee Piyachaturawat, Apichart Suksamrarn Diarylheptanoids of curcuma comosa with inhibitory effects on nitric oxide production in macrophage RAW 264.7 Cells. Natural Product Communications. Vol.10, No.1 (2015), 89-93. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35288
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Diarylheptanoids of curcuma comosa with inhibitory effects on nitric oxide production in macrophage RAW 264.7 Cells
Abstract
Eight new diarylheptanoids, a 1.2:1 mixture of (3S)-And (3R)-1-(4-hydroxyphenyl)-7-phenyl-(4E,6E)-4,6-heptadien-3-ol (1a and 1b), a racemic mixture of (3S)-And (3R)-1-(4-hydroxyphenyl)-3-methoxy-7-phenyl-(4E,6E)-4,6-heptadiene (2a and 2b), a ca. 1:1 mixture of (3S)-And (3R)-1-(4-hydroxy-3-methoxyphenyl)-3-methoxy-7-phenyl)-(4E,6E)-4,6-heptadiene (3a and 3b), 3-Acetoxy-1-(3,4-dihydroxyphenyl)-7-phenylheptan-5-ol (4), (3R)-1-(4,5-dihydroxyphenyl)-7-phenyl-(6E)-6-hepten-3,2-epoxide (5), and thirteen known diarylheptanoids, 6-12, a 3:1 mixture of 13a and 13b, and 14-17, were isolated from the rhizomes of Curcuma comosa from Sakon Nakhon, northeastern part of Thailand. The isolated compounds were evaluated for their antiinflammatory activities on the inhibition of lipopolysaccharide-induced nitric oxide production in macrophage RAW 264.7 cells and the diarylheptanoids 1a and 1b mixture and 14 exhibited potent inhibitory activity.