Publication: Fungal quorum sensing molecules: Role in fungal morphogenesis and pathogenicity
Issued Date
2016-05-01
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ISSN
15214028
0233111X
0233111X
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2-s2.0-84960845249
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Basic Microbiology. Vol.56, No.5 (2016), 440-447
Suggested Citation
Thanwa Wongsuk, Potjaman Pumeesat, Natthanej Luplertlop Fungal quorum sensing molecules: Role in fungal morphogenesis and pathogenicity. Journal of Basic Microbiology. Vol.56, No.5 (2016), 440-447. doi:10.1002/jobm.201500759 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/40817
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Title
Fungal quorum sensing molecules: Role in fungal morphogenesis and pathogenicity
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Abstract
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. When microorganisms live together in high numbers, they need to communicate with each other. To achieve cell-cell communication, microorganisms secrete molecules called quorum-sensing molecules (QSMs) that control their biological activities and behaviors. Fungi secrete QSMs such as farnesol, tyrosol, phenylethanol, and tryptophol. The role of QSMs in fungi has been widely studied in both yeasts and filamentous fungi, for example in Candida albicans, C. dubliniensis, Aspergillus niger, A. nidulans, and Fusarium graminearum. QSMs impact fungal morphogenesis (yeast-to-hypha formation) and also play a role in the germination of macroconidia. QSMs cause fungal cells to initiate programmed cell death, or apoptosis, and play a role in fungal pathogenicity. Several types of QSMs are produced during stages of biofilm development to control cell population or morphology in biofilm communities. This review article emphasizes the role of fungal QSMs, especially in fungal morphogenesis, biofilm formation, and pathogenicity. Information about QSMs may lead to improved measures for controlling fungal infection.