Publication: Early management of sepsis in medical patients in rural Thailand: A single-center prospective observational study
Issued Date
2019-12-02
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ISSN
20520492
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2-s2.0-85076210587
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Intensive Care. Vol.7, No.1 (2019)
Suggested Citation
Kristina E. Rudd, Viriya Hantrakun, Ranjani Somayaji, Suchart Booraphun, Chaiyaporn Boonsri, Annette L. Fitzpatrick, Nicholas P.J. Day, Prapit Teparrukkul, Direk Limmathurotsakul, T. Eoin West Early management of sepsis in medical patients in rural Thailand: A single-center prospective observational study. Journal of Intensive Care. Vol.7, No.1 (2019). doi:10.1186/s40560-019-0407-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51250
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Title
Early management of sepsis in medical patients in rural Thailand: A single-center prospective observational study
Abstract
© 2019 The Author(s). Background: The burden of sepsis is highest in low- A nd middle-income countries, though the management of sepsis in these settings is poorly characterized. Therefore, the objective of this study was to assess the early management of sepsis in Thailand. Methods: Pre-planned analysis of the Ubon-sepsis study, a single-center prospective cohort study of Thai adults admitted to the general medical wards and medical intensive care units (ICUs) of a regional referral hospital with community-acquired sepsis. Results: Between March 2013 and January 2017, 3,716 patients with sepsis were enrolled. The median age was 59 years (IQR 44-72, range 18-101), 58% were male, and 88% were transferred from other hospitals. Eighty-six percent of patients (N = 3,206) were evaluated in the Emergency Department (ED), where median length of stay was less than 1 hour. Within the first day of admission, most patients (83%, N = 3,089) were admitted to the general medical wards, while 17% were admitted to the ICUs. Patients admitted to the ICUs had similar age, gender, and comorbidities, but had more organ dysfunction and were more likely to receive measured sepsis management interventions. Overall, 84% (N = 3,136) had blood cultures ordered and 89% (N = 3,308) received antibiotics within the first day of hospital admission. Among the 3,089 patients admitted to the general medical wards, 38% (N = 1,165) received an adrenergic agent, and 21% (N = 650) received invasive mechanical ventilation. Overall mortality at 28 days was 21% (765/3,716), and 28-day mortality in patients admitted to the ICUs was higher than that in patients admitted to the general medical wards within the first day (42% [263/627] vs. 16% [502/3,089], p < 0.001). Conclusions: Sepsis in a regional referral hospital in rural Thailand, where some critical care resources are limited, is commonly managed on general medical wards despite high rates of respiratory failure and shock. Enhancing sepsis care in the ED and general wards, as well as improving access to ICUs, may be beneficial in reducing mortality.