Publication: Shedding of HIV-1 Subtype E in Semen and Cervico-Vaginal Fluid
Issued Date
1997-01-01
Resource Type
ISSN
01252208
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2-s2.0-2542423854
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.80, No.6 (1997), 347-356
Suggested Citation
Ruengpung Sutthent, Pongsakdi Chaisilwattana, Anuvat Roongpisuthipong, Piyanot Wirachsilp, Kwonchid Samrangsarp, Pattrawan Chaiyakul, Pilaipan Puthavathana, Chantapong Wasi Shedding of HIV-1 Subtype E in Semen and Cervico-Vaginal Fluid. Journal of the Medical Association of Thailand. Vol.80, No.6 (1997), 347-356. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/18197
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Title
Shedding of HIV-1 Subtype E in Semen and Cervico-Vaginal Fluid
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Abstract
The uneven expansion of HIV-1 subtypes in each transmitted group raises the possibility that some viruses have less/more potential by qualitative/quantitative for heterosexual transmission compared to others. In Thailand, HTV-1 subtype E is mainly spread via heterosexual route and accounts for about 95 per cent of the infected cases. To determine whether high sexual infectivity of HIV-1 subtype E is due to the presence of a virus in genital fluid, we conducted a study to characterize shedding of HIV-1 in seminal and cervico-vaginal fluids of 30 HIV-1 subtype E infected Thai couples by PCR and virus isolation methods. All subjects had no HIV-associated diseases and other sexually transmitted diseases. HIV-1 subtype E DNA was detected in 22/30 (77.33%) of cervico-vaginal and also 22/30 (77.33%) of seminal fluid samples. The isolation rate of HIV-1 from semen and cervico-vaginal secretion was 36.67 per cent and 16.67 per cent, respectively. Number of HIV-I subtype E DNA copies in the blood is reversely correlated with the number of blood CD4+ T cells, while that in genital fluid was not related to CD4+ T cell count. An increase in shedding of HIV- DNA subtype E in female genital tract compared to other HIV subtypes reported by other investigators might be one reason to explain the rapid spread of subtype E by heterosexual transmission in Thailand.