Publication: Choroidal ruptures after adjuvant intravitreal injection of bevacizumab for aggressive posterior retinopathy of prematurity
Issued Date
2010-07-01
Resource Type
ISSN
14765543
07438346
07438346
Other identifier(s)
2-s2.0-77954232653
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Perinatology. Vol.30, No.7 (2010), 497-499
Suggested Citation
L. O. Atchaneeyasakul, A. Trinavarat Choroidal ruptures after adjuvant intravitreal injection of bevacizumab for aggressive posterior retinopathy of prematurity. Journal of Perinatology. Vol.30, No.7 (2010), 497-499. doi:10.1038/jp.2009.166 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29597
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Choroidal ruptures after adjuvant intravitreal injection of bevacizumab for aggressive posterior retinopathy of prematurity
Author(s)
Other Contributor(s)
Abstract
In recent times, laser treatment combined with intravitreal bevacizumab (Avastin) has been used rarely as early investigations to treat patients with aggressive posterior retinopathy of prematurity (ROP). We describe choroidal ruptures that were documented at 10 weeks after this combined treatment in a preterm infant born at 28 weeks gestation with a birth weight of 1190 g. Aggressive posterior ROP was diagnosed at the age of 6 weeks. Initial treatment included bilateral laser ablation, followed immediately by intravitreal bevacizumab (IVB, 0.75 mg) in the right eye. On day 5, a remarkable regression of plus sign and fibrovascular proliferation was noted only in the right eye. At this point, additional laser treatment combined with IVB was given in the left eye, which dramatically resolved plus disease and neovascularization. At 10 weeks after IVB in the left eye, two sites of choroidal ruptures were revealed along the posterior edges of laser scars. There was no evidence of choroidal neovascularization associated with the choroidal ruptures. Choroidal rupture may occur shortly after laser ablation plus IVB treatment for aggressive posterior ROP. This occurrence requires recognition to determine whether it is actually related to the treatment. Long-term follow-up is important for understanding the nature and progression of this potentially serious complication. © 2010 Nature America, Inc. All rights reserved.