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Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis

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dc.contributor.authorC. Ridruechaien_US
dc.contributor.authorS. Mahasirimongkolen_US
dc.contributor.authorJ. Phromjaien_US
dc.contributor.authorH. Yanaien_US
dc.contributor.authorN. Nishidaen_US
dc.contributor.authorI. Matsushitaen_US
dc.contributor.authorJ. Ohashien_US
dc.contributor.authorN. Yamadaen_US
dc.contributor.authorS. Moolphateen_US
dc.contributor.authorS. Summanapanen_US
dc.contributor.authorC. Chuchottawornen_US
dc.contributor.authorW. Manosuthien_US
dc.contributor.authorP. Kantipongen_US
dc.contributor.authorS. Kanitvittayaen_US
dc.contributor.authorP. Sawanpanyalerten_US
dc.contributor.authorN. Keichoen_US
dc.contributor.authorS. Khusmithen_US
dc.contributor.authorK. Tokunagaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherJapan Anti-Tuberculosis Associationen_US
dc.contributor.otherThailand Ministry of Public Healthen_US
dc.contributor.otherJapan Anti-Tuberculosis Associationen_US
dc.contributor.otherUniversity of Tokyoen_US
dc.contributor.otherNational Center for Global Health and Medicineen_US
dc.contributor.otherUniversity of Tsukubaen_US
dc.contributor.otherChiang Rai Regional Hospitalen_US
dc.date.accessioned2018-09-24T08:44:21Z
dc.date.available2018-09-24T08:44:21Z
dc.date.issued2010-07-01en_US
dc.description.abstractChromosome 5q31 spans the T helper (Th) 2-related cytokine gene cluster, which is potentially important in Th1/Th2 immune responses. The chromosome 5q23.2-31.3 has been recently identified as a region with suggestive evidence of linkage to tuberculosis in the Asian population. With the aim of fine-mapping a putative tuberculosis susceptibility locus, we investigated a family-based association test between the dense single nucleotide polymorphism (SNP) markers within chromosome 5q31 and tuberculosis in 205 Thai trio families. Of these, 75 SNPs located within candidate genes covering SLC22A4, SLC22A5, IRF1, IL5, RAD50, IL13, IL4, KIF3A and SEPT8 were genotyped using the DigiTag2 assay. Association analysis revealed the most significant association with tuberculosis in haplotypes comprising SNPs rs274559, rs274554 and rs274553 of SLC22A5 gene (PGlobal2.02 × 10-6), which remained significant after multiple testing correction. In addition, two haplotypes within the SLC22A4 and KIF3A region were associated with tuberculosis. Haplotypes of SLC22A5 were significantly associated with the expression levels of RAD50 and IL13. The results show that the variants carried by the haplotypes of SLC22A4, SLC22A5 and KIF3A region potentially contribute to tuberculosis susceptibility among the Thai population. © 2010 Macmillan Publishers Limited All rights reserved.en_US
dc.identifier.citationGenes and Immunity. Vol.11, No.5 (2010), 416-422en_US
dc.identifier.doi10.1038/gene.2010.26en_US
dc.identifier.issn14765470en_US
dc.identifier.issn14664879en_US
dc.identifier.other2-s2.0-77954886721en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14594/28684
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954886721&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleAssociation analysis of susceptibility candidate region on chromosome 5q31 for tuberculosisen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77954886721&origin=inwarden_US
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