Publication: Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry
Issued Date
2019-03-01
Resource Type
ISSN
18790844
13889842
13889842
Other identifier(s)
2-s2.0-85058157463
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
European Journal of Heart Failure. Vol.21, No.3 (2019), 297-307
Suggested Citation
Chanchal Chandramouli, Tiew Hwa Katherine Teng, Wan Ting Tay, Jonathan Yap, Michael R. MacDonald, Jasper Tromp, Limin Yan, Bambang Siswanto, Eugenio B. Reyes, Tachapong Ngarmukos, Cheuk Man Yu, Chung Lieh Hung, Inder Anand, A. Mark Richards, Lieng Hsi Ling, Judith G. Regensteiner, Carolyn S.P. Lam, A. Mark Richards, Carolyn S.P. Lam, Inder Anand, Chung Lieh Hung, Lieng Hsi Ling, Houng Bang Liew, Calambur Narasimhan, Sang Weon Park, Eugenio Reyes, Bambang B. Siswanto, Wataru Shimizu, Shu Zhang Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry. European Journal of Heart Failure. Vol.21, No.3 (2019), 297-307. doi:10.1002/ejhf.1358 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51845
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN-HF registry
Author(s)
Chanchal Chandramouli
Tiew Hwa Katherine Teng
Wan Ting Tay
Jonathan Yap
Michael R. MacDonald
Jasper Tromp
Limin Yan
Bambang Siswanto
Eugenio B. Reyes
Tachapong Ngarmukos
Cheuk Man Yu
Chung Lieh Hung
Inder Anand
A. Mark Richards
Lieng Hsi Ling
Judith G. Regensteiner
Carolyn S.P. Lam
A. Mark Richards
Carolyn S.P. Lam
Inder Anand
Chung Lieh Hung
Lieng Hsi Ling
Houng Bang Liew
Calambur Narasimhan
Sang Weon Park
Eugenio Reyes
Bambang B. Siswanto
Wataru Shimizu
Shu Zhang
Tiew Hwa Katherine Teng
Wan Ting Tay
Jonathan Yap
Michael R. MacDonald
Jasper Tromp
Limin Yan
Bambang Siswanto
Eugenio B. Reyes
Tachapong Ngarmukos
Cheuk Man Yu
Chung Lieh Hung
Inder Anand
A. Mark Richards
Lieng Hsi Ling
Judith G. Regensteiner
Carolyn S.P. Lam
A. Mark Richards
Carolyn S.P. Lam
Inder Anand
Chung Lieh Hung
Lieng Hsi Ling
Houng Bang Liew
Calambur Narasimhan
Sang Weon Park
Eugenio Reyes
Bambang B. Siswanto
Wataru Shimizu
Shu Zhang
Other Contributor(s)
Manila Doctors Hospital
Care Hospital Hyderabad
Universitas Indonesia
Mackay Memorial Hospital Taiwan
University of Colorado School of Medicine
Nippon Medical School
University of Otago
National University of Singapore
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
VA Medical Center
Changi General Hospital
University of Minnesota Medical School
University of Groningen, University Medical Center Groningen
National Heart Centre, Singapore
Chinese University of Hong Kong
Queen Elizabeth Hospital
Cardiovascular Research Institute
Fuwai Cardiovascular Hospital
Sejong General Hospital
Care Hospital Hyderabad
Universitas Indonesia
Mackay Memorial Hospital Taiwan
University of Colorado School of Medicine
Nippon Medical School
University of Otago
National University of Singapore
Faculty of Medicine, Ramathibodi Hospital, Mahidol University
VA Medical Center
Changi General Hospital
University of Minnesota Medical School
University of Groningen, University Medical Center Groningen
National Heart Centre, Singapore
Chinese University of Hong Kong
Queen Elizabeth Hospital
Cardiovascular Research Institute
Fuwai Cardiovascular Hospital
Sejong General Hospital
Abstract
© 2018 The Authors. European Journal of Heart Failure © 2018 European Society of Cardiology Aims: To examine sex differences in clinical characteristics, echocardiographic features, quality of life and 1-year death or heart failure (HF) hospitalization outcomes in patients with/without diabetes mellitus (DM). Methods and results: Utilizing the Asian Sudden Cardiac Death in HF (ASIAN-HF) registry, 5255 patients (mean age 59.6 ± 13.1, 78% men) with symptomatic HF with reduced ejection fraction (HFrEF) were stratified by DM status to address the research aims. Despite similar prevalence of DM between Asian men (43%) and women (42%), the odds of DM increased at lower body mass index in women vs. men (≥ 23 vs. ≥ 27.5 kg/m 2 , P interaction = 0.014). DM was more strongly related to chronic kidney disease in women vs. men [adjusted odds ratio (OR) 1.85, 95% confidence interval (CI) 1.33–2.57 vs. OR 1.32, 95% CI 1.11–1.56, P interaction = 0.009]. Sex also modified the relationship between DM and left ventricular geometry (P interaction = 0.003), whereby DM was associated with a more concentric left ventricular geometry in women than men. Women had lower quality of life than men (P < 0.001), in both DM and non-DM groups. DM was associated with worse composite outcomes at 1 year in women vs. men [hazard ratio (HR) 1.79, 95% CI 1.24–2.60 vs. HR 1.32, 95% CI 1.12–1.56; P interaction = 0.005). Conclusions: Asian women with HFrEF were more likely to have DM despite a lean body mass index, a greater burden of chronic kidney disease and more concentric left ventricular geometry, compared to men. Furthermore, DM confers worse quality of life, irrespective of sex, and a greater risk of adverse outcomes in women than men. These data underscore the need for sex-specific approaches to diabetes in patients with HF.