Publication: Antimalarial drugs reduce cytoadherence and rosetting of Plasmodium falciparum
Issued Date
1996-01-01
Resource Type
ISSN
00221899
Other identifier(s)
2-s2.0-0030062755
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.173, No.3 (1996), 691-698
Suggested Citation
R. Udomsangpetch, B. Pipitaporn, S. Krishna, B. Angus, S. Pukrittayakamee, I. Bates, Y. Suputtamongkol, D. E. Kyle, N. J. White Antimalarial drugs reduce cytoadherence and rosetting of Plasmodium falciparum. Journal of Infectious Diseases. Vol.173, No.3 (1996), 691-698. doi:10.1093/infdis/173.3.691 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17765
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Title
Antimalarial drugs reduce cytoadherence and rosetting of Plasmodium falciparum
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Abstract
The in vivo and in vitro effects of antimalarials on cytoadherence and rosette formation were studied in 17 patients with severe and 46 with uncomplicated falciparum malaria. Cytoadherence was increased in severe malaria (P < .001). Artesunate and artemether were more potent than quinine in inhibiting both adherence properties. Artesunate was the most rapidly acting drug tested, producing >50% inhibition of both cytoadherence and rosetting in vivo and in vitro within 2 h of drug exposure. Exposure to quinine for ≥4 h in vivo reduced rosetting by >50%, but not cytoadherence. Quinine did not reduce cytoadherence or rosetting significantly in vitro with exposure times of ≤8 h. These results suggest that artemisinin derivatives are more effective than quinine in preventing pathologic processes in parasitized erythrocytes that contribute to microvascular obstruction in severe malaria.