Publication: The Association of vitamin D status and fasting glucose according to body fat mass in young healthy Thais
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Issued Date
2013
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eng
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Mahidol University
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BioMed Central
Bibliographic Citation
BMC Endocrine Disorders. Vol. 13, (2013), 60
Suggested Citation
Hataikarn Nimitphong, La-or Chailurkit, Suwannee Chanprasertyothin, Piyamitr Sritara, Boonsong Ongphiphadhanakul The Association of vitamin D status and fasting glucose according to body fat mass in young healthy Thais. BMC Endocrine Disorders. Vol. 13, (2013), 60. doi:10.1186/1472-6823-13-60 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/2702
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Title
The Association of vitamin D status and fasting glucose according to body fat mass in young healthy Thais
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Abstract
Background: Existing inconclusive data on the relationship between vitamin D status and human glucose
homeostasis suggests that other factors, such as adiposity, might influence this relationship. The present study
aimed to investigate the association between 25-hydroxyvitamin D [25(OH)D] and fasting plasma glucose (FPG) in
the context of different amounts of total body fat in a healthy community-based population in Bangkok, Thailand.
Methods: This cross-sectional study was a part of health survey of employees of the Electricity Generating Authority
of Thailand. There were 1,990 healthy subjects (72.8% male) in this study. Total body fat was measured by
bioelectrical impedance analysis. Total serum 25(OH)D, 25(OH)D3 and 25(OH)D2 were measured by LC-MS/MS.
Results: Age (r = 0.134, p < 0.001) and FPG (r = 0.089, p < 0.001) were positively correlated with 25(OH)D levels, while
total body fat mass (r = −0.049, p = 0.03) were negatively correlated with 25(OH)D levels. 25(OH)D levels were higher
in males than in females (65.0 ± 0.5 vs. 53.5 ± 0.5 nmol/L, p < 0.001). After controlling for age, gender and total fat
mass, FPG was no longer correlated with 25(OH)D. However, when subjects were stratified according to fat-free
mass tertiles and controlled for age and gender, there was a positive, although weak association between 25(OH)D
levels and FPG (p = 0.01) in the lowest tertile.
Conclusions: We therefore speculate that adiposity might influence the relationship of vitamin D status and FPG.