Publication:
Prevalence of genotypic HIV-1 drug resistance in Thailand, 2002

dc.contributor.authorEkachai Jenwitheesuken_US
dc.contributor.authorChotip Watitpunen_US
dc.contributor.authorAsda Vibhagoolen_US
dc.contributor.authorWasun Chantratitaen_US
dc.contributor.otherUniversity of Washington School of Medicineen_US
dc.contributor.otherMahidol Universityen_US
dc.date.accessioned2018-07-24T03:25:34Z
dc.date.available2018-07-24T03:25:34Z
dc.date.issued2003-03-06en_US
dc.description.abstractBackground: The prices of reverse transcriptase (RT) inhibitors in Thailand have been reduced since December 1, 2001. It is expected that reduction in the price of these inhibitors may influence the drug resistance mutation pattern of HIV-1 among infected people. This study reports the frequency of HIV-1 genetic mutation associated with drug resistance in antiretroviral-treated patients from Thailand. Methods: Genotypic resistance testing was performed on samples collected in 2002 from 88 HIV-1 infected individuals. Automated DNA sequencing was used to genotype the HIV-1 polymerase gene isolated from patients' plasma. Results: Resistance to protease inhibitors, nucleoside and non-nucleoside reverse transcriptase inhibitors were found in 10 (12%), 42 (48%) and 19 (21%) patients, respectively. The most common drug resistance mutations in the protease gene were at codon 82 (8%), 90 (7%) and 54 (6%), whereas resistant mutations at codon 215 (45%), 67 (40%), 41 (38%) and 184 (27%) were commonly found in the RT gene. This finding indicates that genotypic resistance to nucleoside reverse transcriptase inhibitors was prevalent in 2002. The frequency of resistant mutations corresponding to non-nucleoside reverse transcriptase inhibitors was three times higher-, while resistant mutation corresponding to protease inhibitors was two times lower than those frequencies determined in 2001. Conclusion: This study shows that the frequencies of RT inhibitor resistance mutations have been increased after the reduction in the price of RT inhibitors since December 2001. We believe that this was an important factor that influenced the mutation patterns of HIV-1 protease and RT genes in Thailand. © 2003 Jenwitheesuk et al;licensee BioMed Central Ltd.en_US
dc.identifier.citationAnnals of Clinical Microbiology and Antimicrobials. Vol.2, (2003)en_US
dc.identifier.doi10.1186/1476-0711-2-4en_US
dc.identifier.issn14760711en_US
dc.identifier.other2-s2.0-2542475871en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/20914
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=2542475871&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.titlePrevalence of genotypic HIV-1 drug resistance in Thailand, 2002en_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=2542475871&origin=inwarden_US

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