Publication: Methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) in relation to homocysteine concentration in overweight and obese thais
Issued Date
2005-03-01
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ISSN
01251562
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2-s2.0-20444445106
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Mahidol University
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SCOPUS
Bibliographic Citation
Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.2 (2005), 459-466
Suggested Citation
Kittisak Thawnashom, Rungsunn Tungtrongchitr, Songsak Petmitr, Praneet Pongpaew, Benjaluck Phonrat, Anchalee Tungtrongchitr, Frank Peter Schelp Methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) in relation to homocysteine concentration in overweight and obese thais. Southeast Asian Journal of Tropical Medicine and Public Health. Vol.36, No.2 (2005), 459-466. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17053
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Title
Methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) in relation to homocysteine concentration in overweight and obese thais
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Abstract
We analyzed the association between MTHFR (C677T) gene polymorphism with serum concentrations of homocysteine, folate, and vitamin B12in 37 male and 112 female overweight/obese Thai volunteers (BMI ≥25.00 kg/m2), and compared them with 23 male and 90 female control subjects (BMI=18.5-24.99 kg/m2). Statistically significant higher levels of serum homocysteine were found in the overweight/obese subjects than the control subjects (p<0.05). Serum folic acid levels in the overweight/obese subjects were significantly lower than the control subjects (p< 0.05). When the data were grouped according to homocysteine concentration and MTHFR gene polymorphism, there were significantly higher homocysteine concentrations in the overweight/obese subjects than the control subjects in wild type gene polymorphism (CC) in the hyperhomocysteine group (homocysteine >10.0 mmol/l) (p<0.05), but in genotype polymorphism (CC, CT, TT) there were lower folic acid and vitamin B12concentrations in the overweight/obese subjects than in the control subjects. In the hyperhomocysteine groups, there was no significant difference in the frequencies of MTHFR (C677T) gene polymorphism between the overweight/obese subjects and the control subjects. Folic acid and gene polymorphism were found to be significantly related to the overweight/obese and control groups in logistic regression analysis (p<0.05). The results support the supposition that folic acid is more important than vitamin B12.