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Atropisomeric myristinins: Selective COX-2 inhibitors and antifungal agents from Myristica cinnamomea

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dc.contributor.authorSupaporn Sawadjoonen_US
dc.contributor.authorPrasat Kittakoopen_US
dc.contributor.authorKanyawim Kirtikaraen_US
dc.contributor.authorVanicha Vichaien_US
dc.contributor.authorMorakot Tanticharoenen_US
dc.contributor.authorYodhathai Thebtaranonthen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherThailand National Center for Genetic Engineering and Biotechnologyen_US
dc.date.accessioned2018-07-24T02:58:32Z
dc.date.available2018-07-24T02:58:32Z
dc.date.issued2002-08-09en_US
dc.description.abstractThe first naturally occurring atropisomeric flavans, myristinins B (2), ] (2a), E (4), and F (4a), together with their corresponding trans-isomers, myristinins A (1) and D (3), were isolated from the CH2Cl2 extract of Myristica cinnamomea fruits. Compounds 1, the mixture of 2 and 2a, and the mixture of 4 and 4a, exhibited antifungal activity against Candida albicans with IC50 values ranging from 5.9 to 8.8 μg/mL, and they selectively inhibited the enzyme cyclooxygenase-2 (COX-2).en_US
dc.identifier.citationJournal of Organic Chemistry. Vol.67, No.16 (2002), 5470-5475en_US
dc.identifier.doi10.1021/jo020045den_US
dc.identifier.issn00223263en_US
dc.identifier.other2-s2.0-0037047548en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/20123
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037047548&origin=inwarden_US
dc.subjectChemistryen_US
dc.titleAtropisomeric myristinins: Selective COX-2 inhibitors and antifungal agents from Myristica cinnamomeaen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0037047548&origin=inwarden_US

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