Publication: Association of HLA-DRB1*1502 - DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais
2
Issued Date
2002-06-22
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ISSN
00012815
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2-s2.0-0036016263
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Mahidol University
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SCOPUS
Bibliographic Citation
Tissue Antigens. Vol.59, No.2 (2002), 113-117
Suggested Citation
M. Sirikong, N. Tsuchiya, D. Chandanayingyong, S. Bejrachandra, P. Suthipinittharm, K. Luangtrakool, D. Srinak, R. Thongpradit, U. Siriboonrit, K. Tokunaga Association of HLA-DRB1*1502 - DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens. Vol.59, No.2 (2002), 113-117. doi:10.1034/j.1399-0039.2002.590206.x Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/20059
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Title
Association of HLA-DRB1*1502 - DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais
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Abstract
In this study, we investigated the association of HLA-DRB1 and DQB1 with Thai patients with SLE. A highly significant increase in the frequency of DRB1*1502 and DQB1*0501 was found in SLE patients compared with normal controls. DRB1*1501 and DRB1*1602 were also slightly increased. In contrast, DRB1*1202 and DQB1*0301 were decreased, and DRB1*0406 and DRB1*1401 were not found in the patients' group. The haplotype analysis revealed that DRB1*1502 - DQB1*0501 was most strongly associated with SLE, and also suggested a primary role for DRB1 rather than DQB1. Taken together with the previous report which demonstrated the association of the same haplotype in Taiwan, our present observations strongly suggested that DRB1*1502 - DQB1*0501 is the major HLA haplotype that confers susceptibility to SLE in the South-east Asian populations.