Publication: An open, baseline controlled evaluation of sertraline safety and efficacy in the treatment of depression in Thai patients
Issued Date
2001-01-01
Resource Type
ISSN
01252208
Other identifier(s)
2-s2.0-0035028349
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.84, No.1 (2001), 54-62
Suggested Citation
Vudhichai Boonyanaruthee, Sudsabuy Chulakadabba, Vira Khuangsirikul, Thienchai Ngamthipwatthana, Benjaporn Panyayong, Pichai Saengcharnchai, Tinnakorn Chan-Ob, Suparat Ekasawin, Panpimol Lotrakul, Raviwan Nivataphan, Pairat Pruksachatkunakorn, Anant Thanaprasertgorn An open, baseline controlled evaluation of sertraline safety and efficacy in the treatment of depression in Thai patients. Journal of the Medical Association of Thailand. Vol.84, No.1 (2001), 54-62. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26896
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Title
An open, baseline controlled evaluation of sertraline safety and efficacy in the treatment of depression in Thai patients
Abstract
An open, baseline controlled study of sertraline in depressed patients was conducted in 6 treatment sites. Eighty-two patients between 20-82 years of age with DSM III-R diagnosis of a depressive illness received sertraline 50-200 mg/day. Among evaluable patients, there was a significant reduction in depressive symptoms at the final visit. A statistically significant change from baseline in Montgomery Asberg Depression Rating Scale (MADRS), Hospital Anxiety Depression Rating Scale (HAD), and Clinical Global Impression Severity of Illness Scale (CGI-S) scores was demonstrated. On the basis of MADRS criterion, 96.0 per cent of patients responded and on the basis of CGI-S criterion, 86.6 per cent of patients responded. In 73.2 per cent of patients the final sertraline dosage was 50 mg. All-cause adverse events were recorded in 35 patients (42.7%), whereas 22 (26.8%) had adverse events that were judged treatment-related. The most frequently reported events were nausea and headache. Overall, the patients tolerated sertraline very well. The results of the study suggest that sertraline is an effective, well-tolerated and safe treatment for depression in Thai patients.