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Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

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dc.contributor.authorGunter Schumannen_US
dc.contributor.authorLachlan J. Coinen_US
dc.contributor.authorAnbarasu Lourdusamyen_US
dc.contributor.authorPimphen Charoenen_US
dc.contributor.authorKaren H. Bergeren_US
dc.contributor.authorDavid Staceyen_US
dc.contributor.authorSylvane Desrivièresen_US
dc.contributor.authorFazil A. Alieven_US
dc.contributor.authorAnokhi A. Khanen_US
dc.contributor.authorNajaf Aminen_US
dc.contributor.authorYurii S. Aulchenkoen_US
dc.contributor.authorGeorgy Bakalkinen_US
dc.contributor.authorStephan J. Bakkeren_US
dc.contributor.authorBeverley Balkauen_US
dc.contributor.authorJoline W. Beulensen_US
dc.contributor.authorAinhoa Bilbaoen_US
dc.contributor.authorRudolf A. De Boeren_US
dc.contributor.authorDelphine Beuryen_US
dc.contributor.authorMichiel L. Botsen_US
dc.contributor.authorElemi J. Breetvelten_US
dc.contributor.authorStéphane Cauchien_US
dc.contributor.authorChristine Cavalcanti-Proençaen_US
dc.contributor.authorJohn C. Chambersen_US
dc.contributor.authorToni Kim Clarkeen_US
dc.contributor.authorNorbert Dahmenen_US
dc.contributor.authorEco J. De Geusen_US
dc.contributor.authorDanielle Dicken_US
dc.contributor.authorFrancesca Duccien_US
dc.contributor.authorAlanna Eastonen_US
dc.contributor.authorHoward J. Edenbergen_US
dc.contributor.authorTõnu Esken_US
dc.contributor.authorAlberto Fernández-Medardeen_US
dc.contributor.authorTatiana Forouden_US
dc.contributor.authorNelson B. Freimeren_US
dc.contributor.authorJean Antoine Giraulten_US
dc.contributor.authorDiederick E. Grobbeeen_US
dc.contributor.authorSimonetta Guarreraen_US
dc.contributor.authorDaniel F. Gudbjartssonen_US
dc.contributor.authorAnna Liisa Hartikainenen_US
dc.contributor.authorAndrew C. Heathen_US
dc.contributor.authorVictor Hesselbrocken_US
dc.contributor.authorAlbert Hofmanen_US
dc.contributor.authorJouke Jan Hottengaen_US
dc.contributor.authorMatti K. Isohannien_US
dc.contributor.authorJaakko Kaprioen_US
dc.contributor.authorKay Tee Khawen_US
dc.contributor.authorBrigitte Kuehnelen_US
dc.contributor.authorJaana Laitinenen_US
dc.contributor.authorStéphane Lobbensen_US
dc.contributor.authorJian'an Luanen_US
dc.contributor.authorMassimo Manginoen_US
dc.contributor.authorMatthieu Maroteauxen_US
dc.contributor.authorGiuseppe Matulloen_US
dc.contributor.authorMark I. McCarthyen_US
dc.contributor.authorChristian Muelleren_US
dc.contributor.authorGerjan Navisen_US
dc.contributor.authorMattijs E. Numansen_US
dc.contributor.authorAlejandro Núñezen_US
dc.contributor.authorDale R. Nyholten_US
dc.contributor.authorCharlotte N. Onland-Moreten_US
dc.contributor.authorBen A. Oostraen_US
dc.contributor.authorPaul F. O'Reillyen_US
dc.contributor.authorMiklos Palkovitsen_US
dc.contributor.authorBrenda W. Penninxen_US
dc.contributor.authorSilvia Polidoroen_US
dc.contributor.authorAnneli Poutaen_US
dc.contributor.authorInga Prokopenkoen_US
dc.contributor.authorFulvio Riccerien_US
dc.contributor.authorEugenio Santosen_US
dc.contributor.authorJohannes H. Smiten_US
dc.contributor.authorNicole Soranzoen_US
dc.contributor.authorKijoung Songen_US
dc.contributor.authorUlla Sovioen_US
dc.contributor.authorMichael Stumvollen_US
dc.contributor.authorIda Surakken_US
dc.contributor.authorThorgeir E. Thorgeirssonen_US
dc.contributor.authorUnnur Thorsteinsdottiren_US
dc.contributor.authorClaire Troakesen_US
dc.contributor.authorThorarinn Tyrfingssonen_US
dc.contributor.authorAnke Tönjesen_US
dc.contributor.authorCuno S. Uiterwaalen_US
dc.contributor.authorAndre G. Uitterlindenen_US
dc.contributor.authorPim Van Der Harsten_US
dc.contributor.authorYvonne T. Van Der Schouwen_US
dc.contributor.otherKing's College Londonen_US
dc.contributor.otherImperial College Londonen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNational Health Serviceen_US
dc.contributor.otherErnest Gallo Clinic and Research Centeren_US
dc.contributor.otherVirginia Commonwealth Universityen_US
dc.contributor.otherErasmus University Medical Centeren_US
dc.contributor.otherUppsala Universiteten_US
dc.contributor.otherUniversity of Groningen, University Medical Center Groningenen_US
dc.contributor.otherInsermen_US
dc.contributor.otherUniversite Paris-Sud XIen_US
dc.contributor.otherUniversity Medical Center Utrechten_US
dc.contributor.otherZentralinstitut fur Seelische Gesundheiten_US
dc.contributor.otherCNRS Centre National de la Recherche Scientifiqueen_US
dc.contributor.otherJohannes Gutenberg Universitat Mainzen_US
dc.contributor.otherIndiana University-Purdue University Indianapolisen_US
dc.contributor.otherUniversity of Tartuen_US
dc.contributor.otherEstonian Biocentreen_US
dc.contributor.otherUniversidad de Salamancaen_US
dc.contributor.otherJane & Terry Semel Institute for Neuroscience & Human Behavioren_US
dc.contributor.otherUniversite Pierre et Marie Curieen_US
dc.contributor.otherInstitute for Scientific Interchange Foundationen_US
dc.contributor.otherUniversity of Icelanden_US
dc.contributor.otherOulun Yliopistoen_US
dc.contributor.otherWashington University in St. Louis, School of Medicineen_US
dc.contributor.otherUniversity of Connecticuten_US
dc.contributor.otherVU University Medical Centeren_US
dc.contributor.otherHelsingin Yliopistoen_US
dc.contributor.otherNational Institute for Health and Welfareen_US
dc.contributor.otherInstitute for Molecular Medicineen_US
dc.contributor.otherUniversity of Cambridgeen_US
dc.contributor.otherHelmholtz Center Munich German Research Center for Environmental Healthen_US
dc.contributor.otherTyoterveyslaitosen_US
dc.contributor.otherMedical Research Councilen_US
dc.contributor.otherUniversita degli Studi di Torinoen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherFriedrich-Alexander-Universität Erlangen-Nürnbergen_US
dc.contributor.otherQueensland Institute of Medical Researchen_US
dc.contributor.otherSemmelweis Egyetemen_US
dc.contributor.otherInstitute for Research in Extramural Medicine - EMGOen_US
dc.contributor.otherLeiden University Medical Center - LUMCen_US
dc.contributor.otherWellcome Trust Centre for Human Geneticsen_US
dc.contributor.otherWellcome Trust Sanger Instituteen_US
dc.contributor.otherGlaxoSmithKlineen_US
dc.contributor.otherUniversitat Leipzigen_US
dc.contributor.otherVogur Samtök Áhugafólks um Áfengis Addiction Treatment Centeren_US
dc.contributor.otherCentre Hospitalier Universitaire Vaudoisen_US
dc.contributor.otherLudwig-Maximilians-Universitat Munchenen_US
dc.contributor.otherKlinikum der Universitat Munchenen_US
dc.contributor.otherHammersmith Hospitalen_US
dc.contributor.otherHealth Protection Agencyen_US
dc.date.accessioned2018-05-03T08:47:00Z
dc.date.available2018-05-03T08:47:00Z
dc.date.issued2011-04-26en_US
dc.description.abstractAlcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in autism susceptibility candidate 2 gene (AUTS2) was associated with alcohol consumption at genome-wide significance (P = 4 x 10 -8 to P = 4 x 10 -9 ). We found a genotype-specific expression of AUTS2 in 96 human prefrontal cortex samples (P = 0.026) and significant (P < 0.017) differences in expression of AUTS2 in whole-brain extracts of mice selected for differences in voluntary alcohol consumption. Downregulation of an AUTS2 homolog caused reduced alcohol sensitivity in Drosophila (P < 0.001). Our finding of a regulator of alcohol consumption adds knowledge to our understanding of genetic mechanisms influencing alcohol drinking behavior.en_US
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America. Vol.108, No.17 (2011), 7119-7124en_US
dc.identifier.doi10.1073/pnas.1017288108en_US
dc.identifier.issn10916490en_US
dc.identifier.issn00278424en_US
dc.identifier.other2-s2.0-79955569025en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/12920
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955569025&origin=inwarden_US
dc.subjectMultidisciplinaryen_US
dc.titleGenome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumptionen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955569025&origin=inwarden_US

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