Publication: Computed tomography evaluation of intracranial vascular calcification in major ischemic stroke patients (Vascular Territory) - Its distribution and association with vascular risk factors: A Retrospective Trial
Issued Date
2015-01-01
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01252208
01252208
01252208
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2-s2.0-84927539361
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.98, No.4 (2015), 414-422
Suggested Citation
Pipat Chiewvit, Siri On Tritrakarn, Temporn Kraumak Computed tomography evaluation of intracranial vascular calcification in major ischemic stroke patients (Vascular Territory) - Its distribution and association with vascular risk factors: A Retrospective Trial. Journal of the Medical Association of Thailand. Vol.98, No.4 (2015), 414-422. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36570
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Title
Computed tomography evaluation of intracranial vascular calcification in major ischemic stroke patients (Vascular Territory) - Its distribution and association with vascular risk factors: A Retrospective Trial
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Abstract
© 2015, Medical Association of Thailand. All rights reserved. Objective: Our objective was to determine the distribution of intracranial atherosclerotic calcification, its association with risk factors, and cerebrovascular events in patients with major ischemic stroke. Material and Method: In this retrospective study, 327 patients who underwent CT scan of brain were included and the clinical parameters were recorded. Two neuroradiologists evaluated the non-contrast axial CT images for any of intracranial arteries, based on a standard CT scoring system for extent (0-4) and thickness (0-4). The composite CT score for extent and thickness of these vascular segments or vessels were recorded on all patients. Results: Based on of MDCT features, 155 major ischemic stroke and 172 non-ischemic stroke were enrolled. The highest prevalence of calcification was seen in intracranial internal carotid artery (IICA) (73%), and less commonly in the vertebral artery (8%). There were higher prevalence of intracranial artery calcification in ischemic stroke patients than non-ischemic stroke patients (82% vs. 52%, p<0.0001). Hypertension (OR = 1.903, 95% CI: 1.019-3.552, p<0.05), intracranialartery calcification (OR = 2.147, 95% CI: 1.143-4.033, p<0.05), moderate degree of calcification (OR = 2.631, 95% CI: 1.299-5.260, p<0.05), and severe degree of calcification (OR = 3.479, 95% CI: 1.500-8.068, p<0.05) were found to be independently associated with ischemic stroke. Conclusion: Significant intracranial atherosclerosis as determined by severe CT calcification had higher incidence in ischemic stroke patients. Intracranial artery calcification with moderate and severe degree of calcification and hypertension were independently significant associated with ischemic stroke. CT calcification score might serve as an indicator of intracranial atherosclerotic disease and might be useful in predicting ischemic stroke.